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FLASH GENE
Symbol APOA2 contributors: - updated : 04-04-2007
HGNC name apolipoprotein A-II
HGNC id 601
Corresponding disease
APOA2 apolipoprotein A-II deficiency
Location 1q21-q23      Physical location : 161.192.082 - 161.193.418
Genatlas name see TSG1M
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
motif repetitive sequence   ALU
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   highly
Lymphoid/Immunespleen   highly
Visualeyeretina   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short N terminal domain and a C terminal domain with a variable number of lipid-binding amphipathic helices
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Apoa2 (57.14 pc)
    homolog to murine Apoa2 (61.22 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in lipid transporter
  • stabilizing HDL (high density lipoprotein) structure by its association with lipids, and affecting the HDL metabolism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) APOA2
    Susceptibility
  • to low HDL- cholesterol
  • to increased visceral adipose tissue in premenopausal white women
    • Variant & Polymorphism other
  • association between the T265C APOA-II polymorphism and levels of visceral adipose tissue in premenopausal white women
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS