Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol APMAP contributors: mct - updated : 08-06-2011
HGNC name chromosome 20 open reading frame 3
HGNC id 13238
Location 20p11.21      Physical location : -
Genatlas name adipocyte plasma membrane-associated protein
Synonym symbol(s) BSCV, C20orf3, UNQ1869/PRO4305, DD16
DNA
TYPE functioning gene
STRUCTURE 29.85 kb     9 Exon(s)
motif repetitive sequence
MAPPING cloned Y linked N status confirmed
regionally located downstream and tightly linked to CST7
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2251 46 416 - 2008 18513186
EXPRESSION
Rna function mRNAs are present in several tissues, but among the tissues tested, a remarkably higher level of expression was found in white adipose tissue
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselcapillary    Homo sapiens
Digestiveliver   highly Homo sapiens
Endocrinethyroid   predominantly
Nervousnerve   highly
Reproductivefemale systemplacenta  highly Homo sapiens
Urinarykidneynephronrenal capsuleglomerulushighly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
Connectivebone  moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion highly in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single N-glycosylation site and an N-terminal hydrophobic stretch of 19 AAs forming a transmembrane segment, indicating that it is a glycosylated membrane-bound protein
  • extracellular C-terminal domain of APMAP is required for the function of APMAP in adipocyte differentiation
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • strictosidine synthase family
  • lactonohydrolase super family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • single-pass type II membrane protein
  • translocates from the endoplasmatic reticulum to the plasma membrane during adipocyte differentiation
  • basic FUNCTION
  • may play a role in adipocyte differentiation
  • may function as a novel protein involved in the cross-talk of mature adipocytes with the environment
  • having analogies with PON (paraoxonase) family members, and can represent a new member of this important protein family present at the cellular level
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PPARG (through a functional PPARG binding site)
  • cell & other
    REGULATION
    induced by strongly induced by the PPARG ligand rosiglitazone in adipocytes in adipose tissue
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS