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FLASH GENE
Symbol APLP2 contributors: mct/npt - updated : 12-05-2010
HGNC name amyloid beta (A4) precursor-like protein 2
HGNC id 598
Location 11q24.3      Physical location : 129.939.715 - 130.014.705
Synonym name
  • CDEI box-binding protein
  • amyloid precursor protein homolog HSD-2
  • Synonym symbol(s) APPL2, APPH, B16D6, CDEBP
    DNA
    TYPE functioning gene
    STRUCTURE 74.90 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    FLJ40224 11q24.2 hypothetical protein FLJ40224 LOC387820 11 similar to DnaJ (Hsp40) homolog, subfamily B, member 6 isoform a; heat shock protein J2 LOC283166 11q24.3 hypothetical LOC283166 ETS1 11q23.3 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) LOC387821 11 hypothetical gene supported by BC039676 FLI1 11q24 Friend leukemia virus integration 1 KCNJ1 11q25 potassium inwardly-rectifying channel, subfamily J, member 1 KCNJ5 11q24 potassium inwardly-rectifying channel, subfamily J, member 5 MGC35558 11q24.3 hypothetical protein MGC35558 P53AIP1 11q24 p53-regulated apoptosis-inducing protein 1 RICS 11q24-q25 p53-regulated apoptosis-inducing protein 1 LOC387822 11 similar to hypothetical protein BARX2 11q25 BarH-like homeobox 2 LOC387823 11 LOC387823 LOC120224 11q24.3 hypothetical protein BC016153 NFRKB 11q24-q25 nuclear factor related to kappa B binding protein PRDM10 11q25 PR domain containing 10 LOC253665 11q24.3 similar to Transcription elongation factor B polypeptide 2 (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Elongin B) (EloB) (Elongin 18 kDa subunit) APLP2 11q24 amyloid beta (A4) precursor-like protein 2 ST14 11q24-q25 suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin) HSPC063 11q24.3 HSPC063 protein ADAMTS8 11q25 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 ADAMTS15 11q25 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15 LOC390277 11 similar to Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (BCL2-like 7 protein) FLJ39058 11q25 hypothetical protein FLJ39058 LOC387824 11 LOC387824 MGC43033 11q25 hypothetical protein MGC43033 SNX19 11q25 sorting nexin 19 LOC219797 11q25 similar to KIAA1838 HNT 11q25 neurotrimin OPCML 11q25 opioid binding protein/cell adhesion molecule-like
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3791 - 751 - von der Kammer (1994)
    16 - 3623 - 695 - von der Kammer (1994)
    13 - 3104 - 522 - von der Kammer (1994)
    18 - 3827 - 763 - von der Kammer (1994)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
     liver    
    Endocrineparathyroid   highly
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    Respiratorylung    
     respiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    Cardiovascularendothelial cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion sperm
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a KPI domain similar to the KPI domain of APP
  • HOMOLOGY
    Homologene
    FAMILY
  • Alzheimer's amyloid precursor protein (APP)family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    intracellular,nucleus
    basic FUNCTION
  • putatively involved in the mitotic segregation of the genome and establishment of the proper nuclear structure
  • inhibiting thrombosis
  • having a putative role in sperm function (Fardilha 2007)
  • modulates the stability and endocytosis of the MHC class I molecule K(d) (Tuli 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    likewise stimulates neurite lengthening (Young-Pearse 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mouse