Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol APLNR contributors: mct/npt - updated : 19-06-2010
HGNC name apelin receptor
HGNC id 339
Location 11q12.1      Physical location : 57.001.053 - 57.004.927
Synonym name
  • angiotensin II receptor-like 1
  • APJ (apelin) receptor
  • G-protein coupled receptor APJ
  • Synonym symbol(s) APJ, FLJ90771, MGC45246, AGTRL1, APJR, HG11
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 3.87 kb     1 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 3905 - 380 - Sarzani (2007)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Lymphoid/Immunespleen    
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • stimulating a phosphotyrosine phosphatase which inhibits guanylate cyclase
  • having a physiological role in mechanisms of water intake and fluid retention and suggest an anti-diuretic effect of apelin (Roberts 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor of apelin (APLN), apelin-AGTRL1 signaling pathway emerges as an important novel mediator of cardiovascular control
  • APLN, APLNR signaling is a potent regulator of endothelial MEF2C function in the developing cardiovascular system
  • APLNR controls a regulatory CER1-SMARCD3 pathway in pluripotent stem cell cardiomyogenesis (pMID: 23787002)
  • cell & other
    REGULATION
    Other regulated in a tissue-dependent manner and according to the severity of insulin resistance (Dray 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in aortic valve stenosis, of the apelin-APLNR signaling pathway (Peltonen 2009)
    Susceptibility to brain infarction
    Variant & Polymorphism SNP SNP in the 5'-flanking region (SNP30, rs9943582,
    154G/A) is significantly associated with brain infarction
    Candidate gene
    Marker
    Therapy target apelin-APLNR signaling pathway, is a possible novel target for drug discovery in calcified aortic valve disease by suppressing chemotaxis, angiogenesis and osteoblast activity, all of which are well-documented phenomena in the disease process (Peltonen 2009)
    ANIMAL & CELL MODELS