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FLASH GENE
Symbol APIP contributors: - updated : 04-05-2006
HGNC name APAF1 interacting protein
HGNC id 17581
Location 11p13      Physical location : 34.903.842 - 34.937.939
Synonym name likely ortholog of mouse monocyte macrophage 19
Synonym symbol(s) APIP2, MMRP19, CGI-29
DNA
TYPE functioning gene
STRUCTURE 34.00 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vessel   moderately
Digestivemouthtongue   
 pharynx   highly
 salivary gland   predominantly
 stomach    
Endocrineadrenal gland   highly
 pancreas    
Lymphoid/Immunethymus    
 tonsils   moderately
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectiveadipose   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to chicken APIP (86.1pc)
ortholog to murine Apip (93.8pc)
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • functioning to inhibit muscle ischemic damage by binding to APAF1 in the APAF1/caspase-9 apoptosis pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds to the CARD of APAF1 in competition with caspase-9
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS