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FLASH GENE
Symbol APIP contributors: mct - updated : 25-01-2017
HGNC name APAF1 interacting protein
HGNC id 17581
Location 11p13      Physical location : 34.903.842 - 34.937.939
Synonym name likely ortholog of mouse monocyte macrophage 19
Synonym symbol(s) APIP2, MMRP19, CGI-29, CGI29, hAPIP
EC.number 4.2.1.109
DNA
TYPE functioning gene
STRUCTURE 34.12 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1285 - 242 - 2014 24367089
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vessel   moderately
Digestivemouthtongue   
 pharynx   highly
 salivary gland   predominantly
 stomach    
Endocrineadrenal gland   highly
 pancreas    
Lymphoid/Immunethymus    
 tonsils   moderately
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectiveadipose   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region of APIP that is missing in the short isoform is required for activity
  • HOMOLOGY
    interspecies ortholog to chicken APIP (86.1pc)
    ortholog to murine Apip (93.8pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • functioning to inhibit muscle ischemic damage by binding to APAF1 in the APAF1/caspase-9 apoptosis pathway
  • involvement of APIP in the methionine salvage pathway, which plays a key role in many biological functions like cancer, apoptosis, microbial proliferation and inflammation
  • inhibit two main types of programmed cell death, apoptosis and pyroptosis, and was recently found to be associated with cancers and inflammatory diseases
  • act as a 5-methylthioribulose-1-phosphate dehydratase, in the methionine salvage pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the CARD of APAF1 in competition with caspase-9
  • plays an essential role in ERBB3 signaling as a positive regulator for tumorigenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    of APIP and UACA in non-small cell lung carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS