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FLASH GENE
Symbol APH1B contributors: mct/npt - updated : 13/09/2008
HGNC name anterior pharynx defective 1 homolog B (C. elegans)
HGNC id 24080
Location 15q22.2      Physical location : 63.569.748 - 63.601.324
Synonym name
  • presenilin stabilization factor-like
  • anterior pharynx defective 1B-like
  • gamma-secretase subunit APH-1B
  • Synonym symbol(s) PSFL, APH-1B, PRO1328, TAAV688, DKFZp564D0372
    DNA
    TYPE functioning gene
    STRUCTURE 28.32 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 939 28.3 257 - Mehrle (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Nervousbrainhindbrainmedulla oblongata  
     brainforebraincerebral cortexfrontal cortexhighly
    Visualeyeanterior segmentiris  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebonesubchondral  
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
  • APH-1 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • required for the activity and accumulation of gamma-secretase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of gamma-secretase complex, composed of four non-covalently bound transmembrane proteins presenilin, nicastrin APH1A, APH1B, PSENEN, that is responsible for the intramembranous cleavage of amyloid precursor protein (APP) and NOTCH
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with APH-1A and PEN2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS