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FLASH GENE
Symbol APEX2 contributors: mct/npt - updated : 10/09/2008
HGNC name APEX nuclease (apurinic/apyrimidinic endonuclease) 2
HGNC id 17889
Location Xp11.22      Physical location : 55.026.779 - 55.034.211
Synonym name
  • APEX nuclease-like 2
  • DNA-(apurinic or apyrimidinic site) lyase 2
  • apurinic or apyrimidinic sitelyase 2
  • Synonym symbol(s) APE2, XTH2, APEXL2
    EC.number 4.2.99.18
    DNA
    TYPE functioning gene
    STRUCTURE 7.43 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1991 57 518 - Burkovics (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila Apc
    homolog to E.coli exo III
    Homologene
    FAMILY
  • DNA repair enzymes AP/exoA family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,nucleus
    basic FUNCTION
  • having a weak class II AP endonuclease activity
  • playing an important role in both nuclear and mitochondrial base excision repair (BER) (PCNA-dependent BER pathway in the nucleus)
  • exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity
  • playing a role as a 3'-5' exonuclease
  • CELLULAR PROCESS nucleotide, repair, base excision repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS