SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,organelle,lysosome
|
| intracellular,nucleus
|
text
| localized to endosomes and/or the trans Golgi network (TGN) |
basic FUNCTION
| clathrin adaptor, playing a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes |
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maybe associated with and regulating protein trafficking in the endosomes and/or transGolgi network |
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JUN and AP3B1 are involved in the formation of distinct types of clathrin-coated vesicles, each of which is characterized by the incorporation of specific cargo membrane proteins |
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with SLC15A4, and Hermansky-Pudlak syndrome proteins, are required for Toll-like receptor signaling in plasmacytoid dendritic cells |
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required for the function of the IRF7 endosome |
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AP3B1 complex is required for signaling through TLR7 and TLR9 to induce activation of IFN but not proinflammatory cytokine genes |
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novel function for AP3B1 and RUFY1 in regulating lysosome positioning through an interorganellar pathway |