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FLASH GENE
Symbol AP2B1 contributors: - updated : 20-05-2006
HGNC name adaptor-related protein complex 2, beta 1 subunit
HGNC id 563
Location 17q11.2-q12      Physical location : 33.914.281 - 34.053.433
Synonym name
  • adaptin,beta 2
  • clathrin-associated/assembly/adaptor protein, large, beta 1
  • plasma membrane adaptor HA2/AP2 adaptin beta subunit
  • Synonym symbol(s) ADTB2, CLAPB1, AP105B, AP2-BETA
    DNA
    TYPE functioning gene
    STRUCTURE 139.00 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CCT6B 17q11.2 chaperonin containing TCP1, subunit 6B (zeta 2) MGC20398 17q21.1 hypothetical protein MGC20398 LIG3 17q11.2-q12 ligase III, DNA, ATP-dependent LOC117584 17q21.1 fring RAD51L3 17q11 RAD51-like 3 (S. cerevisiae) DKFZp434H2215 17q21.1 hypothetical protein DKFZp434H2215 FLJ10458 17q21.1 Notchless gene homolog (Drosophila) CMYA4 17q21.1 cardiomyopathy associated 4 FLJ40154 17q21.1 hypothetical protein FLJ40154 MGC19764 17q21.1 hypothetical protein MGC19764 FLJ34922 17q21.1 hypothetical protein FLJ34922 FLJ10260 17q21.1 hypothetical protein FLJ10260 FLJ31952 17q21.1 hypothetical protein FLJ31952 LOC342615 17q21.1 similar to Adenylosuccinate synthetase 2 (IMP--aspartate ligase 2) (AdSS 2) (AMPSase 2) LOC342616 17q21.1 similar to TAF5L protein LOC342618 17q21.1 similar to FLJ34922 protein PEX12 17q21.1 peroxisomal biogenesis factor 12 AP2B1 17q11.2-q12 adaptor-related protein complex 2, beta 1 subunit VTS58635 GAR17 17q21.1 GAS2-related protein LOC146853 17q21.1 LOC146853 MMP28 17q11-q21.1 matrix metalloproteinase 28 TAF15 17q11.1-q11.2 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa FLJ32830 17q21.1 hypothetical protein FLJ32830 CCL5 17q11.2 chemokine (C-C motif) ligand 5 LOC390786 17 hypothetical gene supported by AL833376 LOC390787 17 similar to KIAA0563 protein RAD52B 17q11.2 RAD52B LOC57151 17q11.2 lysozyme homolog CCL16 17q11.2 chemokine (C-C motif) ligand 16 CCL14 17q11.2 chemokine (C-C motif) ligand 14 CCL14-CCL15 17q21.1 chemokine ligand 14, chemokine ligand 15 transcription unit CCL15 17q11.2 chemokine (C-C motif) ligand 15 CCL23 17q11.2 chemokine (C-C motif) ligand 23 CCL18 17q11.2 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) CCL3 17q11.2 chemokine (C-C motif) ligand 3 CCL4 17q11.2 chemokine (C-C motif) ligand 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 5772 - 951 - Rappoport
    - - 5730 - 937 - Rappoport
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two globular adaptin domains interconnected by a variable and potentially flexible stalk domain
  • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY adaptor complexes large subunits complex
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text cytoplasmic face of clathrin coated vesicles
    basic FUNCTION
  • potentially mediating rapid internalization
  • playing a major role in clathrin coat formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of assembly protein complex AP-2, clathrin coat assembly complex linking clathrin to receptors in coated pits and vesicles
  • heterotetramer composed of two large chains (alpha and beta),a medium chain (AP50) and a small chain (AP17)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with both cargo and clathrin
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS