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FLASH GENE
Symbol AP2A2 contributors: npt/ - updated : 30-03-2006
HGNC name adaptor-related protein complex 2, alpha 2 subunit
HGNC id 562
Location 11p15.5      Physical location : 925.840 - 1.012.239
Synonym name
  • alpha-adaptin C
  • Huntingtin interacting protein J
  • Huntingtin yeast partner J
  • adaptin, alpha B
  • clathrin-associated/assembly/adaptor protein, large, alpha 2
  • plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
    • Synonym symbol(s) HYPJ, ADTAB, CLAPA2, KIAA0899, DKF2P564D1864, HIP9
    DNA
    TYPE functioning gene
    STRUCTURE 86.40 kb     22 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4616 104 939 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Ap2a2 adaptor protein complex AP-2 alpha 2 subunit
    Homologene
    FAMILY
  • adaptor complexes large subunit family
    • CATEGORY adaptor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text endocytic coated vesicles
    basic FUNCTION
  • AP2 adaptor complex linking clathrin to receptors in coated vesicles, clathrin-associated protein complexes are believed to interact with cytoplasmic domains of transmembrane proteins leading to their selection and concentration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of AP-2 adaptor complex, clathrin coat assembly complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HIP1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS