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FLASH GENE
Symbol AP1M1 contributors: mct - updated : 03-09-2012
HGNC name adaptor-related protein complex 1, mu 1 subunit
HGNC id 13667
Location 19p13.2      Physical location : 16.308.664 - 16.346.156
Synonym name
  • clathrin adaptor protein, medium chain mu1B
  • golgi adaptor AP-1 47 kDa protein
  • clathrin coat assembly protein AP47
  • HA1 47 kDa subunit
  • Synonym symbol(s) CLAPM2, AP47, CLTNM, MU-1A
    DNA
    TYPE functioning gene
    STRUCTURE 37.49 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ21438 19p13.12 hypothetical protein FLJ21438 PGRP-L 19p13.12 peptidoglycan recognition protein L precursor FLJ39501 19p13.12 hypothetical protein FLJ39501 LOC390896 19 similar to Cytochrome P450 4F6 (CYPIVF6) LOC388513 19 similar to 60S ribosomal protein L23a CYP4F8 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 8 CYP4F3 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 3 CYP4F12 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 12 OR10H2 19p13.1 olfactory receptor, family 10, subfamily H, member 2 OR10H3 19p13.1 olfactory receptor, family 10, subfamily H, member 3 LOC388514 19 similar to Cytochrome P450 4F12 (CYPIVF12) LOC284433 19p13.12 hypothetical gene supported by NM_013940 OR10H1 19p13.1 olfactory receptor, family 10, subfamily H, member 1 LOC388515 19 LOC388515 LOC339377 19p13.12 similar to 4930572L20Rik protein CYP4F2 19p13.1-p12 cytochrome P450, family 4, subfamily F, polypeptide 2 CYP4F11 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 11 LOC126541 19p13.12 similar to Olfactory receptor 10H4 LOC126537 19p13.12 similar to cytochrome P-450 FLJ25328 19p13.12 hypothetical protein FLJ25328 TPM4 19p13.1 tropomyosin 4 MEL 19p13.1 mel transforming oncogene (derived from cell line NK14)- RAB8 homolog HSH2 19p13.12 mel transforming oncogene (derived from cell line NK14)- RAB8 homolog KIP3 DKFZP586O0120 AP1M1 19p13.2 adaptor-related protein complex 1, mu 1 subunit KLF2 19p13.13-p13.11 Kruppel-like factor 2 (lung) EPS15R 19p13.12 Kruppel-like factor 2 (lung) CALR3 19p13.11 calreticulin 3 FLJ21742 19p13.12 hypothetical protein FLJ21742 CHERP 19p13.1 calcium homeostasis endoplasmic reticulum protein SLC35E1 19p13.12 solute carrier family 35, member E1 CRSP7 19p13.12 cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa MGC2747 19p13.12 hypothetical protein MGC2747 MGC3169 19p13.12 hypothetical protein MGC3169 LOC284434 19p13.12 hypothetical protein LOC284434
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2409 49.7 435 - 1999 10640811
    12 - 2373 48.4 423 - 1999 10640811
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
     polarized cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • adaptor complexes medium subunits family
  • CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • protein sorting from the Golgi network or plasma membrane to lysosomes through the recongnition of tyrosine sorting signals
  • linking clathrin to receptors in coated vesicles
  • mediating basolateral targeting in epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of clathrin-coated vesicles
  • heterotetrameric adaptor complex AP-1 with AP1G, AP1M1/M2, AP1S1/2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLC4A1 (AP1M1 is involved in the SLC4A1 trafficking of kidney alpha-intercalated cells)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS