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FLASH GENE
Symbol AP1M1 contributors: mct - updated : 03-09-2012
HGNC name adaptor-related protein complex 1, mu 1 subunit
HGNC id 13667
Location 19p13.2      Physical location : 16.308.664 - 16.346.156
Synonym name
  • clathrin adaptor protein, medium chain mu1B
  • golgi adaptor AP-1 47 kDa protein
  • clathrin coat assembly protein AP47
  • HA1 47 kDa subunit
  • Synonym symbol(s) CLAPM2, AP47, CLTNM, MU-1A
    DNA
    TYPE functioning gene
    STRUCTURE 37.49 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2409 49.7 435 - 1999 10640811
    12 - 2373 48.4 423 - 1999 10640811
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
     polarized cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • adaptor complexes medium subunits family
  • CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • protein sorting from the Golgi network or plasma membrane to lysosomes through the recongnition of tyrosine sorting signals
  • linking clathrin to receptors in coated vesicles
  • mediating basolateral targeting in epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of clathrin-coated vesicles
  • heterotetrameric adaptor complex AP-1 with AP1G, AP1M1/M2, AP1S1/2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLC4A1 (AP1M1 is involved in the SLC4A1 trafficking of kidney alpha-intercalated cells)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS