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FLASH GENE
Symbol AP1G2 contributors: mct - updated : 04-06-2019
HGNC name adaptor-related protein complex 1, gamma 2 subunit
HGNC id 556
Location 14q11.2      Physical location : 24.028.776 - 24.037.279
Synonym name
  • gamma2-adaptin
  • clathrin-associated/assembly/adaptor protein, large, gamma-2
    • Synonym symbol(s) G2AD
    DNA
    TYPE functioning gene
    STRUCTURE 8.50 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 2876 87 785 - 1998 9762922
    - initiation site 3310 87 785 - 1998 9762922
    different 5'utr
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two globular domains (GAT) one N terminal
  • a ubiquitin-interacting motif, which contributes to its interaction with viral core
  • one C terminal interconnected by a variable and potentially flexible stalk domain, C-terminal ear domains (or gamma-adaptin ear (GAE) domains), that bind to a common set of accessory proteins
    • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • adaptor complexes large subunit family
    • CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • cytoplasmic sole of coated vesicles at the Golgi complex
  • mainly perinuclear
    • basic FUNCTION
  • protein sorting from the Golgi network or plasma membrane to lysosomes through the recongnition of tyrosine sorting signals
  • putative endosomal sorting and trafficking adaptor of the adaptor protein complex family
  • ubiquitin-interacting adaptor, that control hepatitis B virus maturation
  • might act within the multivesicular body (MVB) protein-sorting pathway that is central to receptor down-regulation, lysosome biogenesis, and budding of enveloped viruses
  • is a critical factor in MVB trafficking, which likely is involved in endosome-to-lysosome maturation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • clathrin-associated adaptor protein complex 1 composed of two large subunits one medium and one small subunit
  • component of the hetero tetrameric adaptor complex AP-1 with AP1B1, AP1M1/M2, AP1S1/S2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • the beta 1 and sigma 1 subunits
  • specifically interacts with the ESCRT subunits VPS28 and CHMP2A
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to sudden cardiac arrest
    Variant & Polymorphism SNP associated with sudden cardiac arrest
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS