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FLASH GENE
Symbol AP1G1 contributors: mct - updated : 21-03-3012
HGNC name adaptor-related protein complex 1, gamma 1 subunit
HGNC id 555
Location 16q22.2      Physical location : 71.762.906 - 71.842.976
Synonym name
  • adaptin, gamma
  • golgi adaptor HA1/AP1 adaptin gamma subunit
  • clathrin assembly protein complex 1 gamma large chain
  • Synonym symbol(s) CLAPG1, ADTG
    DNA
    TYPE functioning gene
    STRUCTURE 80.07 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 850 - 825 - Takatsu
    23 - 6841 - 822 - Takatsu
    longer 5'utr
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two globular adaptin domains (GAT)
  • one N terminal
  • one C terminal interconnected by a variable and potentially flexible stalk domain, C-terminal ear domains (or gamma-adaptin ear (GAE) domains), that bind to a common set of accessory proteins
  • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY adaptor complexes large subunits family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,granule
    text membrane in the steady state
    basic FUNCTION
  • transporting ligand-receptor complexes from plasma membrane or Golgi to lysosomes
  • maybe also involved in protein sorting to the basolateral plasma membrane of polarized epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of clathrin-coated vesicles
  • heterotetrameric adaptor complex AP-1 with AP1M1/M2, AP1S1/2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AP1AR interacts with membranes and with AP1G1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS