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FLASH GENE
Symbol AP1AR contributors: mct - updated : 14-07-2012
HGNC name AP-1 complex-associated regulatory protein
HGNC id 28808
Location 4q25      Physical location : 113.152.894 - 113.191.209
Synonym name
  • gamma1-adaptin brefeldin A resistance protein, gamma-BAR
  • hypothetical protein LOC55435
  • chromosome 4 open reading frame 16
  • Gadkin
  • Synonym symbol(s) PRO0971, 2C18, C4orf16, PRO0971, gamma-BAR
    DNA
    TYPE functioning gene
    STRUCTURE 38.31 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2911 34 302 - 2005 15775984
    9 - 2812 - 269 - 2005 15775984
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus,nucleolus
    text
  • peripheral membrane protein localized to the trans-Golgi network (TGN)
  • basic FUNCTION
  • role as a regulator of endosomal membrane traffic critically depends on complex formation with both AP1 and KIF5
  • role of AP1 and AP1AR in the traffic of secretory endo-lysosomes
  • trans-Golgi network (TGN)/endosomally localized peripheral membrane protein , and a modulator of adaptor protein (AP)-1-mediated endosomal membrane traffic
  • is a negative regulator of ARP2/3 function
  • negatively regulates cell spreading, size, and motility via sequestration of ARP2/3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    unconventional endo-secretory pathway requires the adaptor protein complexes AP1, AP1AR (which recruits AP1 by binding to the gamma1 subunit), and AP2, but not AP3
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct interaction with gamma1-adaptin (GGA1), that is crucial for membrane association and thus the function of the AP-1 complex in living cells
  • directly associates with the clathrin adaptor AP1 and with the motor protein kinesin KIF5, thereby potentially regulating EV (endosomal vesicles) dynamics
  • interacts with membranes and with AP1G1
  • directly binds to ARP2/3 via a conserved tryptophan-based acidic cluster motif reminiscent of ARP2/3-binding sequences of nucleation-promoting factors (NPFs) but fails to facilitate ARP2/3-mediated actin assembly
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    loss of SHARPIN, similar to loss of Gadkin (AP1AR), is associated with an elevated propensity of cell to migrate, suggesting that signal-dependent control of cell shape and motility is under spatiotemporal control imparted by activators and inhibitors acting at multiple stages of the pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS