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FLASH GENE
Symbol AOC3 contributors: mct - updated : 09-02-2013
HGNC name amine oxidase, copper containing 3 (vascular adhesion protein 1)
HGNC id 550
Location 17q21.31      Physical location : 41.003.200 - 41.010.138
Synonym name
  • vascular adhesion protein 1
  • semicarbazide-sensitive amine oxidase
  • vascular adhesion protein 1 splice variant 2, VAP-1A3
    • Synonym symbol(s) VAP1, HPAO, SSAO, VAP-1
    EC.number 1.4.3.6/ 1.4.3.21
    DNA
    TYPE functioning gene
    STRUCTURE 6.94 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    PTRF 17q21.2 polymerase I and transcript release factor ATP6V0A1 17q21.3 ATPase, H+ transporting, lysosomal V0 subunit a isoform 1 NAGLU 17q21.1 N-acetylglucosaminidase, alpha- (Sanfilippo disease IIIB) HSD17BP1 17q11-q21 hydroxysteroid (17-beta) dehydrogenase pseudogene 1 HSD17B1 17q21.1 hydroxysteroid (17-beta) dehydrogenase 1 DPCK 17q12-q21 bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase TCFL4 17q21.1 transcription factor-like 4 HUMGT198A 17q12-q21 GT198, complete ORF LOC162427 17q21.31 hypothetical protein LOC162427 TUBG1 17q21 tubulin, gamma 1 LOC342578 17q21.31 similar to high mobility group protein homolog HMG4 TUBG2 17q21 tubulin, gamma 2 FLJ21019 17q21.31 hypothetical protein FLJ21019 GPR2 17q21.1 G protein-coupled receptor 2 CNTNAP1 17q21 contactin associated protein 1 EZH1 17q21 enhancer of zeste homolog 1 (Drosophila) RAMP2 17q12-q21.1 receptor (calcitonin) activity modifying protein 2 MGC10540 17q21.31 hypothetical protein MGC10540 PRKWNK4 17q12 protein kinase, lysine deficient 4 HSPC009 17q21 HSPC009 protein FLJ40137 17q21.31 hypothetical protein FLJ40137 BECN1 17q21 beclin 1 (coiled-coil, myosin-like BCL2 interacting protein) PSME3 17q21 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) AOC2 17q21 amine oxidase, copper containing 2 (retina-specific) AOC3 17q21 amine oxidase, copper containing 3 (vascular adhesion protein 1) LOC90586 17q21.31 amine oxidase pseudogene LOC388387 17 hypothetical gene supported by AK055784 G6PC 17q21 glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease) MGC2744 17q21.31 hypothetical protein MGC2744 DKFZp761H0421 17q21.31 hypothetical protein DKFZp761H0421 RPL27 17q21 ribosomal protein L27 IFI35 17q21 interferon-induced protein 35 VAT1 17q21 vesicle amine transport protein 1 homolog (T californica) ARHN 17q21 ras homolog gene family, member N BRCA1 17q21 breast cancer 1, early onset RPL21P4 17q21 ribosomal protein L21 pseudogene 4 NBR2 17q21 neighbor of BRCA1 gene 2 LOC387620 17 membrane component, chromosome 17, surface marker 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4040 - 763 - 2002 12097405
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessels    
    Digestiveliver    
    Lymphoid/Immunelymph node    
    Nervousnerve   highly
    Reproductivefemale systemuterus  highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly Homo sapiensAdult
    Muscularsmooth  highly Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single transmembrane domain at the N terminus and six potential N-glycosylation sites in the extracellular domain
  • a metalloprotease domain
  • a disintegrin-like domain
  • a cysteine-rich domain
  • two imidazole binding sites and key residues for substrate specificity
    • conjugated GlycoP , MetalloP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Aoc3
    intraspecies homolog to hpao
    Homologene
    FAMILY metalloprotease disintegrin family
    CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text adipocyte membrane, type II transmembrane protein
    basic FUNCTION
  • endothelial sialoglycoprotein induced under inflammatory conditions
  • mediating tissue selective lymphocyte binding
  • inducing apoptosis in vascular endothelial cells
  • adhesion protein involved in leukocyte trafficking and inflammatory processes, with a special amine oxidase activity
  • endothelial copper-dependent amine oxidase involved in the recruitment and extravasation of leukocytes at sites of inflammation
  • possible role for adipocyte AOC3 in insulin-signaling and fatty acid metabolism
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism amine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • copper Cu2+
  • topaquinone
    • protein
  • binding between SIGLEC9 and AOC3 (is a novel leukocyte ligand for AOC3and can be used in PET imaging of inflammation and cancer)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target useful as an anti-inflammatory target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    promising anti-inflammatory target
    diabete  
    its substrates might also be of therapeutic value in the treatment of diabetes
    ANIMAL & CELL MODELS