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FLASH GENE
Symbol ANXA7 contributors: mct - updated : 19-10-2007
HGNC name annexin A7
HGNC id 545
Location 10q21.1-q21.2      Physical location : 75.135.188 - 75.173.841
Synonym name
  • lipocortin VII (synexin)
  • annexin VII
  • Synonym symbol(s) LPC7, ANX7, SNX
    DNA
    TYPE functioning gene
    STRUCTURE 38.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    FLJ39116 10q22.2-q22.3 oncoprotein induced transcript 3 PLA2G13 10q22.3 phospholipase A2, group XIII LOC148854 10q22.3 similar to 60S ribosomal protein L17 (L23) P4HA1 10q22.3 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I NUDT13 10q22.3 nudix (nucleoside diphosphate linked moiety X)-type motif 13 HSGT1 10q22.3 nudix (nucleoside diphosphate linked moiety X)-type motif 13 DNAJC9 10q22.3 DnaJ (Hsp40) homolog, subfamily C, member 9 MRPS16 10q22.1 mitochondrial ribosomal protein S16 LOC118491 10q22.3 tetratricopeptide repeat-containing protein ANXA7 10q21.1-q21.2 annexin A7 ZMYND17 10q22.3 zinc finger, MYND domain containing 17 PPP3CB 10q22.3 protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta) C10orf29 MYOZ1 10q22.1 myozenin 1 SYNPO2L 10q22.3 synaptopodin 2-like LOC118704 10q22.3 similar to ARF GTPase-activating protein LOC389978 10 similar to Ribosome biogenesis protein BMS1 homolog GLUDP3 10q22.1 glutamate dehydrogenase pseudogene 3 SEC24C 10q22.3 SEC24 related gene family, member C (S. cerevisiae) FUT11 10q22.3 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) LOC118487 10q22.3 similar to RIKEN cDNA 1110001O19 LOC196752 10q22.3 similar to CG32542-PA KIAA0913 10q22.3 KIAA0913 protein NDST2 10q22 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 CAMK2G 10q22.3 calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing polyA site 2110 50.3 466 - Magendzo
    13 exons
    - splicing polyA site 2176 51 488 brain, cardiac,skeletal muscle Magendzo
  • insertion of an exon cassette
  • 14 exons
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrineadrenal glandmedulla   
     neuroendocrinepituitary  highly
     parathyroid   highly
     thyroid   highly
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervousautonomous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a long hydrophobic 167 AA N terminus
  • a C terminal "core" region
  • four repeats homolog to the endonexin fold
  • HOMOLOGY
    interspecies homolog to murine Anxa7
    homolog to C.elegans T07C4.9
    Homologene
    FAMILY
  • annexin family of calcium-dependent phospholipid binding protein
  • CATEGORY tumor suppressor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text stomatin, sorcin, and synexin were shown to locate mainly outside induced GM1 (ganglioside M1) patches in the human erythrocyte membrane
    basic FUNCTION
  • promoting membrane fusion
  • membrane binding protein with voltage-sensitive calcium channel activity, ion selectivity and membrane fusion
  • mediating galectin-3 (LGALS3) translocation to the perinuclear mitochondrial membranes, where it regulates mitochondrial integrity critical for apoptosis regulation
  • ANXA7 and sorcin are cytosolic proteins that are actors in vesicular trafficking and exocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    text voltage dependent calcium channel
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • calcium Ca2+
  • phospholipid
  • protein interacting with LGALS3
    cell & other membrane
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in prostate cancer especially metastatic
    tumoral   LOH    
    in hormone receptor negative breast carcinomas with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Anxa 7 -/- mice (Herr, 2001)