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Symbol ANXA6 contributors: shn/npt - updated : 12-07-2009
HGNC name annexin A6
HGNC id 544
Location 5q33.1      Physical location : 150.480.267 - 150.537.443
Synonym name
  • lipocortin VI
  • annexin-6
  • calelectrin
  • calphobindin II
  • annexin VI (p68)
  • calcium-binding protein p68
  • chromobindin-20
  • Synonym symbol(s) LPC6, P68CB, ANX6, CBP68, CPB-II, p70
    TYPE functioning gene
    STRUCTURE 57.10 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box) (TATA box)
    MAPPING cloned Y linked N status confirmed
    Map cen - D5S640 - D5S470 - ANXA6 - D5S2077 - D5S673 - qter
    Physical map
    PDE6A 5q31.3 phosphodiesterase 6A, cGMP-specific, rod, alpha SLC26A2 5q31.3 solute carrier family 26 (sulfate transporter), member 2 TIGD6 5q32 tigger transposable element derived 6 RPS20P4 5q33-qter ribosomal protein S20 pseudogene 4 CSF1R 5q31.3 colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog RPL7P 5q33.3 ribosomal protein L7 pseudogene PDGFRB 5q31.3 platelet-derived growth factor receptor, beta polypeptide CDX1 5q31.3 caudal type homeo box transcription factor 1 SLC6A7 5q31-q32 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 CAMK2A 5q33.2 calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha LOC340075 5q33.1 similar to RIKEN cDNA 9330196J05 TCOF1 5q32-q33.1 Treacher Collins-Franceschetti syndrome 1 CD74 5q31.3 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) RPS14 5q32 ribosomal protein S14 NDST1 5q31.3-q32 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 SYNPO 5q33.1 synaptopodin MYOZ3 5q33.1 myozenin 3 FLJ10290 5q33.1 hypothetical protein FLJ10290 DCTN4 5q31-q32 dynactin 4 (p62) NID67 5q33.1 putative small membrane protein NID67 LRG47 5q33.1 LRG-47-like protein ZNF300 21 zinc finger protein 300 GPX3 5q23 glutathione peroxidase 3 (plasma) TNIP1 5q32-q33.1 TNFAIP3 interacting protein 1 ANXA6 5q32 annexin A6 DKFZP434C171 5q33.1 DKFZP434C171 protein GM2A 5q32 GM2 ganglioside activator protein SLC36A3 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 3 SLC36A2 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 2 LOC391840 5 similar to Thyroid hormone receptor-associated protein complex 240 kDa component (Trap240) (Activator-recruited cofactor 250 kDa component) (ARC250) LOC391841 5 similar to hypothetical protein DKFZp761H0421 SLC36A1 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 1 FAT2 5q31-q32 FAT tumor suppressor homolog 2 (Drosophila) SPARC 5q32 secreted protein, acidic, cysteine-rich (osteonectin) ATOX1 5q32-q33 ATX1 antioxidant protein 1 homolog (yeast) LOC389338 5 LOC389338 G3BP 5q33.3 LOC389338 GLRA1 5q32 glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) GLULL1 5q33 glutamate-ammonia ligase (glutamine synthase)-like 1
    TRANSCRIPTS type messenger
    text transcription start site contains TATAA and CAAT motifs
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 splicing 2915 75.87 673 - Smith
    25 splicing 2897 75.15 667 - Smith
  • a 26 exons variant
  • missing exon 21
  • lacking VAAEIL (6 amins acids) at the start of the seventh repeat of the eight protein repeat motif
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
    Digestivepharynx   moderately
    Lymphoid/Immunespleen   highly
     thymus   moderately
    Nervousnerve   highly
    Urinarykidney   moderately
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  predominantly
    cell lineage
    cell lines
    at STAGE
  • a relatively short N terminus
  • a C terminal "core" region containing four repeats homolog to the endonexin fold
  • contains 8 annexin repeats
  • conjugated PhosphoP , Other
    interspecies ortholog to anxa6, Danio rerio
    ortholog to ANXA6, Pan troglodytes
    ortholog to Anxa6, Rattus norvegicus
    ortholog to Anxa6, Mus musculus
  • calcium-dependent membrane and phospholipid binding protein
  • annexin family
  • CATEGORY regulatory , transport
    basic FUNCTION
  • mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis
  • regulating the release of calcium Ca2+ from intracellular strores
  • a retinoid binding activity
  • putative roles in adhesion-related cellular processes that contribute to breast cancer progression
  • may play a particular role in the organization of lipid microdomains in Niemann-Pick disease
  • in the presence of calcium, ANXA6 re-located to the fractions enriched in detergent-resistant microdomains only in the Niemann-Pick disease cells, suggestive of ANXA6 participation in organization of these microdomains
    PHYSIOLOGICAL PROCESS exocytosis transport
    a component
    small molecule metal binding, other,
  • calcium Ca2+
  • phospholipid
  • vitamin A (all-trans retinol)
  • protein
  • CD21
  • Ras p21 regulatory protein p120GAP
  • Ca(2+)-regulated EF-hand proteins S100A1 and S100B
  • EBV/C3d receptor (CR2)
  • active H-Ras (HRasG12V)
  • cell & other
  • cytoskeleton in a calcium-dependent manner
  • interacts with membranes in a Ca2+-dependent manner
    induced by EBV
    Other phosphorylated in response to growth factor stimulation
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    contributes to breast cancer progression by promoting the loss of functional cell-cell and/or cell-ECM contacts and anchorage-independent cell proliferation
    Variant & Polymorphism
    Candidate gene
    Therapy target