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FLASH GENE
Symbol ANXA4 contributors: - updated : 29-11-2006
HGNC name annexin A4
HGNC id 542
Location 2p13      Physical location : 69.969.126 - 70.053.594
Synonym name
  • calcimedin 35 beta,chromobindin 4,endonexin 1
  • proliferation-inducing protein 28
  • placental anticoagulant protein II
    • Synonym symbol(s) LPC4, ANX4, PIG28
    DNA
    TYPE functioning gene
    STRUCTURE 44.00 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1982 - 321 widely Dedman, Piljic
    - - - - 321 only in the digestive tract Dedman
    - - - - 321 very restricted Dedman
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     stomach   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a relatively short N terminus
  • a C terminal "core" region made of four repeats homolog to the endonexin fold
    • HOMOLOGY
    interspecies homolog to murine Anxa4
    homolog to C.elegans ZC155.1
    Homologene
    FAMILY annexin family of calcium-dependent phospholipid binding proteins
    CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • lipocortin IV, placental anticoagulant protein II,
    • inhibiting phospholipase A2, promoting membrane fusion
  • may be playing a role in synaptic exocytosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component complexing with rabphilin, and synaptotagmin 1
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide, other,
  • seems to bind one calcium ion with high affinity
  • phospholipid
  • ATP (maybe)
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS