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FLASH GENE
Symbol ANXA3 contributors: mct - updated : 06-02-2008
HGNC name annexin A3
HGNC id 541
Location 4q13-q22      Physical location : 79.472.741 - 79.531.602
Synonym name
  • calelectrin 32.5
  • lipocortin III
  • calcimedin 35 alpha
  • annexin III (lipocortin III, 1,2-cyclic-inositol-phosphate phosphodiesterase, placental anticoagulant protein III, calcimedin 35-alpha)
  • Synonym symbol(s) LPC3, ANX3
    EC.number 3.1.4.36
    DNA
    TYPE functioning gene
    STRUCTURE 57.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1634 - 323 - Park (2005)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Hearing/Equilibriumear   highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a relatively short N terminus
  • a C terminal "core" region with four repeats homolog to the endonexin fold
  • HOMOLOGY
    interspecies homolog to murine Anxa3
    homolog to C.elegans ZC155.1
    Homologene
    FAMILY
  • annexin family
  • calcium-dependent phospholipid-binding protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • placental anticoagulant protein III
  • playing a role in the regulation of cellular growth and in signal transduction
  • inhibiting the phosphalipase A2
  • cleaving of inositol 1,2-cyclic phosphate to form inositol 1-phosphate (1,2-cyclic-inositol-phosphate phosphodiesterase)
  • inducing migration and tube formation of umbilical vein endothelial cells
  • angiogenic factor that induces VEGF production through the HIF-1 pathway
  • involved in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate
  • may also play a role in anti-coagulation
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism purine/pyrimidine
    signaling signal transduction
    inositol phosphate metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • calcium Ca2+
  • phospholipid
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS