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FLASH GENE
Symbol ANXA2 contributors: mct - updated : 15-06-2016
HGNC name annexin A2
HGNC id 537
Location 15q22.2      Physical location : 60.639.350 - 60.690.185
Synonym name
  • calpactin 1 heavy chain
  • lipocortin II
  • chromobindin 8
  • placental anticoagulant protein IV
  • Synonym symbol(s) ANX2L4, LPC2D, P36, ANX2, LIP2, CAL1H, PAP-IV
    DNA
    TYPE functioning gene
    STRUCTURE 50.84 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388124 15 LOC388124 FLJ14957 15q21.2 hypothetical protein FLJ14957 FLJ30973 15q21.2 hypothetical protein FLJ30973 GRINL1A 15q22.1 glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A ALDH1A2 15q21.2 aldehyde dehydrogenase 1 family, member A2 AQP9 15q22.1-q22.2 aquaporin 9 LOC145780 15q21.2 hypothetical LOC145780 LIPC 15q21-q22.2 lipase, hepatic ADAM10 15q22 a disintegrin and metalloproteinase domain 10 KIAA1164 15q21.3 hypothetical protein KIAA1164 LOC390587 15 similar to zinc finger protein 444; endothelial zinc finger protein 2 FLJ13213 15q21.3 hypothetical protein FLJ13213 RNF111 15q21 ring finger protein 111 CCNB2 15q21.3 cyclin B2 MYO1E 15q21-q22 myosin IE LDHL 15q21.3 lactate dehydrogenase A -like LOC390588 15 similar to TGF beta-inducible nuclear protein 1 (Hairy cell leukemia protein 1) (HUSSY-29) MGC26690 15q21.3 hypothetical protein MGC26690 GCNT3 15q21.3 glucosaminyl (N-acetyl) transferase 3, mucin type GTF2A2 15q21.2 general transcription factor IIA, 2, 12kDa BNIP2 15q11.2 BCL2/adenovirus E1B 19kDa interacting protein 2 LOC145767 LOC390589 15 similar to ATP-dependent RNA helicase DDX18 (DEAD-box protein 18) (Myc-regulated DEAD-box protein) (MrDb) FOXB1 15q21-q26 forkhead box B1 ANXA2 15q21-q22 annexin A2 NARG2 15q21.3 NMDA receptor-regulated gene 2 RORA 15q21-q22 RAR-related orphan receptor A HCP38 15q21.3 cytochrome c, somatic pseudogene LOC390590 15 similar to RAR-related orphan receptor A isoform a; RAR-related orphan receptor alpha; retinoic acid receptor-related orphan receptor alpha; transcription factor RZR-alpha; ROR-alpha FLJ20136 LOC145741 15q21.3 hypothetical LOC145741 LOC390591 15 similar to nucleophosmin LOC388125 15 similar to hypothetical LOC237397 FLJ38723 15q21.3 hypothetical protein FLJ38723 TLN2 15q15-q21 talin 2 LOC390592 15 similar to TSH receptor suppressor element-binding protein-1; TSEP-1 TPM1 15q22.1 tropomyosin 1 (alpha) LACTB 15q22.1 lactamase, beta RPS27L 15q21.3 ribosomal protein S27-like LOC51762 PSFL 15q22.1 anterior pharynx defective 1B-like LOC388126 15 LOC388126 FLJ20151 15q22.1 hypothetical protein FLJ20151 CA12 15q22 carbonic anhydrase XII
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 1644 - 339 - 2007 17239928
    13 - 1632 - 357 - 2007 17239928
    13 - 1563 - 339 - 2007 17239928
    14 - 1665 - 339 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Urinarybladder   highly
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificchondrocyte Homo sapiens
    Skeletonosteoblast Homo sapiens
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • a relatively short N-terminal tail domain able to undergo Ca(2+)-independent membrane-binding, and having different roles in the H+- and Ca2+-mediated membrane bridging mechanisms, with S100A10 binding motif is located in the first 12 AAs of the N-terminal domain, but conflicting reports exist as to the importance of N-terminal ANXA2 acetylation with regard to S100A10 binding
  • a C terminal "core" region made of four repeats homolog to the endonexin fold
  • hydrophilic pore
  • secondary structure four compact domains consisting of five alpha-helices each
    conjugated Other
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Anxa2
    homolog to C.elegans Zc155.1
    Homologene
    FAMILY
  • annexin family
  • calcium dependent phospholipid binding protein family
  • CATEGORY regulatory , signaling , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • in the lamina beneath the plasma membrane
  • S100A10 and ANXA2 were also found to localize in the nucleus
  • basic FUNCTION
  • phospholipase A2 inhibitor, involved in an H+-mediated mechanism leading to a novel AnxA2-membrane complex structure
  • playing a role in the regulation of cellular growth and in signal transduction
  • functioning as an autocrine factor which heighten osteoclast formation and bone resorption
  • regulating the production and autoproteolysis of plasmin at the cell surface (prossessing an intrinsic plasmin reductase activity)
  • stimulating both the proliferation and differentiation of osteoclasts precursors through production of GM-CSF(granulocyte-macrophage colony-stimulating factor) and TNFSF11 respectively
  • annexin A2 and SNAP23 are involved in the same pathway in the regulation of lung surfactant secretion
  • able to bridge membranes either as a dimer or as a monomer, respectively
  • regulate F10 signaling specifically in the absence of cell surface tissue factor and may thus play physiological or pathological roles when factor Xa is generated in a tissue factor-depleted environment
  • plays an essential role inMultidrug resistance-induced tumor invasion
  • calcium-dependent phospholipid binding protein has been implicated in VEGF-mediated retinal neovascularization and is upregulated by VEGF in choroid retinal endothelial cells
  • its expression in osteoblasts is under the control of VEGF, which may have implications for both angiogenesis and bone mineralization under low oxygen conditions
  • regulates endothelial morphogenesis through an adherens junction-mediated pathway upstream of AKT1
  • plays an important role in hematopoietic stem cell (HSC) localization to the endosteal/osteoblastic marrow niche
  • may serves as an anchor for CXCL12 to help in the localization of HSCs to the niche
  • participate in processes localized to the cell surface including extracellular protease regulation and cell-cell interactions
  • is a critical regulator in infection-initiated inflammation, which protects the host from excessive inflammatory damage
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development , exocytosis transport
    text skeletal development
    PATHWAY
    metabolism
    signaling signal transduction
  • S100A10/ANXA2/HLTF pathway mediates both neurogenic and behavioral responses to selective serotonin reuptake inhibitors (SSRIs)
  • a component
  • tetramer of 2 light chains (p10 proteins) and 2 heavy chains (p36 proteins)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • calcium Ca2+ (2 ions with high affinity)
  • phospholipid
  • beta(2)GPI
  • protein
  • binds negatively charged phospholipid membranes through either Ca2+-dependent or Ca2+-independent/H+-dependent mechanisms
  • ANXA2, ANXA8, and ANXA9 interacted with proAREG and ADAM17 on the cell surface
  • ANXA2, ANXA8, ANXA9, play an essential role in the ADAM17-mediated ectodomain shedding of EGFR ligands
  • HLTF, chromatin-remodeling factor, is a target for the S100A10/ANXA2 heterotetrameric complex
  • ANXA2 is a well-characterized binding partner for S100A10
  • S100A10/ANXA2 not only increases the DNA-binding affinity of HLTF but also anchors HLTF to the nuclear matrix presumably via the interaction of ANXA2 with actin and PIP2
  • PLG stimulates airway smooth muscle (ASM) cytokine production in a manner regulated by ANXA2
  • ANXA2-S100A10 molecular bridge participates in cell-cell interactions, revealing a hitherto unexplored function of this protein interaction
  • is a lipid raft-associated trafficking factor for SLC12A1
  • plausible new role of ANXA2 in the reduction of PCSK9 protein levels via a translational mechanism
  • S100A10, and not ANXA2, is the primary plasminogen receptor within the ANXA2-S100A10 complex and contributes to the plasmin-mediated effects that were originally ascribed to ANXA2b
  • ANXA2 directly exerted negative regulation of inflammatory responses through TLR4-initiated TICAM2-TICAM1 pathway occurring on endosomes
  • KRT8 binds to ANXA2, a protein known to mediate apoptosis as well as the redox pathway
  • TRIM65 has an essential oncogenic role via ubiquitination of ANXA2 in urothelial carcinoma of the bladder (UCB) pathogenesis
  • cell & other
  • mediating the binding of beta(2) GPI to endothelial cells
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in small cell lung carcinoma
    tumoral     --over  
    in the clear-cell renal cell carcinoma, significant associations with a higher stage, a higher nuclear grade
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • MYH7, IGFBP7, ANXA2, and DES are all excellent candidate plasma biomarkers of heart failure
  • may be new prognostic marker of metastatic pancreatic ductal adenocarcinoma (PDA)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    inhibition of annexin A2 expression in glioma cells could become a new target for glioma therapy
    allergyasthm 
    targeting ANXA2-mediated signaling may provide a novel therapeutic approach to the treatment of airway inflammation in diseases such as chronic asthma
    cancerendocrinepancreas
    may be new and prognostic marker of metastatic pancreatic ductal adenocarcinoma (PDA)
    ANIMAL & CELL MODELS