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FLASH GENE
Symbol ANXA10 contributors: mct - updated : 03-09-2008
HGNC name annexin A10
HGNC id 534
Location 4q33      Physical location : 169.013.706 - 169.108.891
Synonym name annexin 14
Synonym symbol(s) ANX14
DNA
TYPE functioning gene
STRUCTURE 95.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 1428 37 324 - Liu (2002)
- - - - - - Peng (2005)
aberrant expressions of AFP, SPP1 and ANXA10S cooperatively contribute to tumor progression and poor prognosis in hepatocellular carcinoma
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 stomach    
Endocrinepancreas    
Respiratorylung    
Urinarybladder    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four annexin domains
  • HOMOLOGY
    interspecies homolog to murine Anxa10
    Homologene
    FAMILY
  • annexin family
  • calcium-dependent phospholipid-binding protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • progenitor of annexin A6 octad formation via chromosome duplication during early chordate evolution
  • playing a role in the regulation of cellular growth and in signal transduction
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling signal transduction
    inositol phosphate metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Ca2+
  • phospholipid
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy with TP53 mutation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS