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Symbol ANXA1 contributors: mct - updated : 05-10-2011
HGNC name annexin A1
HGNC id 533
Location 9q21.13      Physical location : 75.766.780 - 75.785.307
Synonym name
  • lipocortin 1
  • calpactin 2
  • chromobinding 9
  • Synonym symbol(s) LPC1, ANX1
    TYPE functioning gene
    STRUCTURE 18.53 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    APBA1 9q13-q21 amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) LOC375743 9q21.13 similar to CG3073-PA LOC138255 9q21.13 similar to RIKEN cDNA 1700028P14 MAMDC2 9q21.2 MAM domain containing 2 RNU2P3 9q21.2 RNA, U2 small nuclear pseudogene 3 SMC5L1 9q21.11 SMC5 structural maintenance of chromosomes 5-like 1 (yeast) BTEB1 9q13 basic transcription element binding protein 1 TRPM3 9q21.13 transient receptor potential cation channel, subfamily M, member 3 LOC392348 9 similar to CDC91 cell division cycle 91-like 1; GPI transamidase component C9orf63 9q21.2 chromosome 9 open reading frame 63 TMEM2 9q13-q21 transmembrane protein 2 CGI-67 MGC61599 LOC392349 9 similar to Heat shock 27 kDa protein (HSP 27) (Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein) C9orf57 9q21.2 chromosome 9 open reading frame 57 LOC392350 9 similar to Transcription factor BTF3 (RNA polymerase B transcription factor 3) GDA 9q21.11-21.33 guanine deaminase ZNF216 9q21.11 zinc finger protein 216 TMC1 9q13-q21 transmembrane, cochlear expressed, 1 ALDH1A1 9q21.1 aldehyde dehydrogenase 1 family, member A1 ANXA1 9q13-q21.2 annexin A1 LOC392351 9 similar to tMDC I LOC138971 9q21.31 similar to dipeptidylpeptidase III isoform 1; dipeptidylpeptidase III LOC138972 9q21.31 similar to Centaurin gamma 2 RORB 9q22 RAR-related orphan receptor B TRPM6 9q21.13 transient receptor potential cation channel, subfamily M, member 6 C9orf40 9q21.31 chromosome 9 open reading frame 40 C9orf41 9q21.31 chromosome 9 open reading frame 41 FLJ20559 9q21.31 hypothetical protein FLJ20559 OSTF1 12q24.1-q24.2 osteoclast stimulating factor 1 LOC138932 9q21.31 similar to Hkr1p PCSK5 9q21.3 proprotein convertase subtilisin/kexin type 5 FLJ11149 9q21.31 riboflavin kinase LOC158473 9q21.31 similar to protein 40kD GCNT1 9q13-q21 glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase) LOC392352 9 similar to peptidyl-Pro cis trans isomerase KIAA0367 9q13-q22.1 similar to peptidyl-Pro cis trans isomerase C9orf65 9q21.32 chromosome 9 open reading frame 65
    regionally located located in the DFNB7 interval
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1399 37 346 - 1999 10465305
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   moderately
     liver   moderately
     pharynx   highly
    Endocrinethyroid   highly
    Hearing/Equilibriumear   moderately
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tractlarynx  highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    cell lineage
    cell lines
    at STAGE
  • formyl peptide receptor ligand
  • a relatively short N terminus
  • a C terminal "core" region containing four annexin, functioning by increasing ICAM1 clustering around adherent neutrophils to anchor them to the endothelium and promote transmigration through the transcellular route
  • conjugated Other
    interspecies homolog to C.elegans ZC155.1
    homolog to rattus Anxa1 (89.02 pc)
    homolog to murine Anxa1 (87.28 pc)
  • calcium dependent phospholipid binding proteins
  • annexin family
  • CATEGORY regulatory , transport
        plasma membrane
    text located on the cytosolic face of the plasma membrane
    basic FUNCTION
  • calcium dependent phospholipid binding protein, modulating antiinflammatory response (phospholipase A2 inhibitory activity)
  • involved in the regulation of early delayed glucocorticoid feadback action in the hypothalamo-hypophysial system
  • role of endogenous ANXA1 in the protective and reparative properties of the intestinal mucosal epithelium
  • mediating the glucocorticoid inhibition of cyclic adenosine 3', 5'-monophosphate-stimulated prolactin secretion
  • promoting membrane fusion
  • mediator of the anti-inflammatory actions of endogenous and exogenous glucocorticoids (GC)
  • regulating the MAPK/ERK pathway
  • potent inhibitor of hormone exocytosis in the neuroendocrine system, acting in a paracrine/juxtacrine manner
  • fundamental for brain homeostasis
  • Ca(2+)-dependent membrane binding protein, which has been implicated in membrane trafficking and reorganization
  • important component of phagocytosis that appears to link actin accumulation to different steps of phagosome formation
  • multifunctional, calcium-dependent phospholipid binding protein involved in a host of processes including inflammation, regulation of neuroendocrine signaling, apoptosis, and membrane trafficking
  • may be required for the constitutive activity of IKBKB and NFKB in highly metatstatic breast cancer
  • required for the recruitment of RIPK1 to the IKK complex, which may be important for the activation of NFKB
  • critical for the constitutive activation of NFkB in breast cancer to promote metastasis
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS inflammation , exocytosis transport
    text anti-inflammatory response
    metabolism lipid/lipoprotein
    signaling signal transduction
    lipid metabolism
    a component
    small molecule metal binding, other,
  • calcium Ca2+ (2 to 4 ions with high affinity)
  • calcium- and phospholipid-binding protein
  • protein
  • formyl peptide receptor (FPR)
  • interacting with TSC22D3 (TSC22D3 is a previously unrecognized mechanism of the anti-inflammatory effects of ANXA1)
  • N-terminal tail of ANXA1 can interact with either membranes or S100A11 protein, and it adopts the conformation of an amphipathic alpha-helix upon these interactions
  • binding of annexin A1 to heparin/heparan sulfate is calcium- but not magnesium-dependent
  • can bind to and interact with IKBKG or NEMO, but not IKBKA or IKBKB
  • ANXA1/FPR2 system has an important role in effecting the resolution of cerebral inflammation in sepsis
  • cell & other
    induced by 17 beta-estradiol in CCRF-CEM cells (synthesis and secretion)
    inhibited by exogenous glucorticoids in brain
    phosphorylated by protein kinase C and epidermal growth factor receptor/kinase
    cleavage by the proteinase 3
    Other Ubiquitination of annexin A1 may play an important role in mutagenesis, an initial step of cell transformation
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancers, correlated with KRAS mutation and may be involved in invasive tumor growth and metastasis
    tumoral     --over  
    in lung cancer
    Susceptibility fragile X syndrome: over or low expression in FMR1
    Variant & Polymorphism
    Candidate gene
    Therapy target
    modulating ANXA1 levels has therapeutic potential to suppress breast cancer metastasis
    could be of potential use as a predictive marker for guiding targeted therapy for colorectal cancer