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FLASH GENE
Symbol ANTXR2 contributors: mct/npt - updated : 04/10/2008
HGNC name anthrax toxin receptor 2
HGNC id 21732
Corresponding disease
JHF juvenile hyaline fibromatosis
Location 4q21.21      Physical location : 80.822.772 - 80.994.477
Synonym name capillary morphogenesis protein 2
Synonym symbol(s) ISH, CMG2, CMG-2, FLJ31074, MGC111533, MGC45856, ANTRX2
DNA
TYPE functioning gene
STRUCTURE 171.71 kb     17 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC339966 4q21.22 similar to Gene product with similarity to Ubiquitin binding enzyme CCNG2 4q21.22 cyclin G2 CXCL13 4q21 chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) CNOT6L 4q13.3 CCR4-NOT transcription complex, subunit 6-like MRPL1 4q21.1 mitochondrial ribosomal protein L1 LOC391670 4 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) FRAS1 4q21.21 Fraser syndrome 1 ANXA3 4q13-q22 annexin A3 LOC391671 4 similar to ribosomal protein S21; 40S ribosomal protein S21 BMP2K 4q21.23 BMP2 inducible kinase PAQR3 4q21.23 progestin and adipoQ receptor family member III GK2 4q13 glycerol kinase 2 OR7E94P 4q27 olfactory receptor, family 7, subfamily E, member 94 pseudogene GDEP 4q21.1 olfactory receptor, family 7, subfamily E, member 94 pseudogene ANTXR2 4q21.3 anthrax toxin receptor 2 LOC339991 4q21.3 similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) PRDM8 4q21 PR domain containing 8 FGF5 4q21 fibroblast growth factor 5 MRPS25P1 4q21.23 mitochondrial ribosomal protein S25 pseudogene MGC35043 4q21.3 hypothetical protein MGC35043 BMP3 4p14-q21 bone morphogenetic protein 3 (osteogenic) PRKG2 4q13.1-q21.1 protein kinase, cGMP-dependent, type II GPIG4 COX5BL1 4cen-q31 cytochrome c oxidase subunit Vb-like 1 LOC345258 4q21.3 similar to bridging integrator 2; bridging integrator-2; breast cancer associated protein BRAP1 HNRPD 4q21.1-q21.2 heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) LOC391672 4 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) HNRPDL 4q13-q21 heterogeneous nuclear ribonucleoprotein D-like MASA 4q21.3 E-1 enzyme
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 8058 - 488 - Abrami (2006)
16 - 2314 - 489 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
Lymphoid/Immunespleen    
Reproductivefemale systemplacenta  highly
 female systemuterus  highly
Respiratoryrespiratory tracttrachea  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye, spleen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one VWFA domain
  • N-terminal signal sequence
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • ATR family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text type 1 membrane protein
    basic FUNCTION
  • involved in normal cell interactions with the extracellular matrix
  • playing a role in basement-membrane-matrix homeostasis and achitecture during development and morphogenesis
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS cardiovascular
    text overexpressed in endothelial cells during capillary formation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to collagen IV and laminin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) JHF
    Susceptibility to ankylosing spondylitis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS