basic FUNCTION
| playing a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic protease |
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important regulator of angiogenesis where its expression on activated blood vessels is induced by angiogenic signals |
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crucial mediator of galectin-3-induced angiogenesis in endothelial cells |
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renal tubule ANPEP inhibits Na flux and plays a mechanistic role in salt-adaptation |
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potential role for ANPEP in leukocyte trafficking |
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receptor for one strain of human coronavirus |
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is an important target of tumor vasculature-targeting drugs |
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regulating tumor necrosis facto-alpha-induced apoptosis in neutrophils |
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regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake |
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is a novel, direct activator of intracellular signaling pathways in pathophysiological conditions |
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participates in several functions such as angiogenesis, cell adhesion, metastasis, and tumor invasion |
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ANPEP negatively regulates TLR4 signaling, thereby balancing the innate response by maintaining the inflammatory equilibrium critical to innate immune regulation |
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membrane dimeric metallopeptidase involved in differentiation, development, and proliferative processes of several tissues |
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is a novel negative regulator of mast cell (MC) activation |
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widely expressed cell surface metallopeptidase involved in the migration of cancer and endothelial cells |
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novel role for ANPEP in inducing homotypic aggregation in neutrophils, which results in a transmigration deficiency; this mechanism may be relevant to neutrophil micro-aggregation |
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regulating endothelial invasion and filopodia formation |
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membrane glycoprotein with aminopeptidase activity, expressed on several cell types, including myeloid cells (dendritic cells, monocytes, macrophages, neutrophils) |
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participates in several functions such as proteolytic regulation of bioactive peptides, viral receptor, angiogenesis, and tumor metastasis |