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FLASH GENE
Symbol ANPEP contributors: SGE/mct - updated : 23-09-2019
HGNC name alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)
HGNC id 500
Location 15q26.1      Physical location : 90.328.126 - 90.358.072
Synonym name
  • antigen CD13 (gp150), 150kD, identified by monoclonal antibodies My7, MCS-2, Tk1, MOU28
  • Aminopeptidase N
  • Synonym symbol(s) CD13, PEPN, APN, gp150, LAP1, P150
    EC.number 3.4.11.2
    DNA
    TYPE functioning gene
    STRUCTURE 29.96 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 3662 106 967 - 2018 29789790
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     intestinelarge intestinecolon highly
     stomach   highly
    Nervousbrain   highly Homo sapiens
    Urinarykidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Nervouscentral  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Lymphoid/Immunedendritic cell Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    not specificchondrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY peptidase M1 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text small intestinal and renal microvillar membrane
    basic FUNCTION
  • playing a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic protease
  • important regulator of angiogenesis where its expression on activated blood vessels is induced by angiogenic signals
  • crucial mediator of galectin-3-induced angiogenesis in endothelial cells
  • renal tubule ANPEP inhibits Na flux and plays a mechanistic role in salt-adaptation
  • potential role for ANPEP in leukocyte trafficking
  • receptor for one strain of human coronavirus
  • is an important target of tumor vasculature-targeting drugs
  • regulating tumor necrosis facto-alpha-induced apoptosis in neutrophils
  • regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake
  • is a novel, direct activator of intracellular signaling pathways in pathophysiological conditions
  • participates in several functions such as angiogenesis, cell adhesion, metastasis, and tumor invasion
  • ANPEP negatively regulates TLR4 signaling, thereby balancing the innate response by maintaining the inflammatory equilibrium critical to innate immune regulation
  • membrane dimeric metallopeptidase involved in differentiation, development, and proliferative processes of several tissues
  • is a novel negative regulator of mast cell (MC) activation
  • widely expressed cell surface metallopeptidase involved in the migration of cancer and endothelial cells
  • novel role for ANPEP in inducing homotypic aggregation in neutrophils, which results in a transmigration deficiency; this mechanism may be relevant to neutrophil micro-aggregation
  • regulating endothelial invasion and filopodia formation
  • membrane glycoprotein with aminopeptidase activity, expressed on several cell types, including myeloid cells (dendritic cells, monocytes, macrophages, neutrophils)
  • participates in several functions such as proteolytic regulation of bioactive peptides, viral receptor, angiogenesis, and tumor metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of Ras signaling in angiogenesis and is a limiting factor in angiogenic progression
  • interacting with LGALS3
  • participates in phagocytic processes in dendritic cells and macrophages
  • ANPEP is required for ADAM17 downregulation
  • YWHAE might directly bind to ANPEP, which transmits its signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis
  • functional interaction between FCER1A and ANPEP on mast cell (MC)
  • cell & other
    REGULATION
    inhibited by PROL1
    Other transcription is regulated by the porot-oncogene c-Maf via an atypical response element
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ANPEP activity in tissue and plasma from colorectal cancer (CRC) patients is an independent prognostic factor of survival
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    YWHAE/ANPEP interaction could be a new therapeutic target in osteoarthritis
    cancerhemopathy 
    may be an important target for novel molecular therapy of early stage acute B-cell leukemia
    ANIMAL & CELL MODELS