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FLASH GENE
Symbol ANPEP contributors: SGE - updated : 26-02-2008
HGNC name alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)
HGNC id 500
Location 15q25-q26      Physical location : 90.328.126 - 90.358.072
Synonym name
  • antigen CD13 (gp150), 150kD, identified by monoclonal antibodies My7, MCS-2, Tk1, MOU28
  • Synonym symbol(s) CD13, PEPN, APN, gp150, LAP1
    EC.number 3.4.11.2
    DNA
    TYPE functioning gene
    STRUCTURE 21.00 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 3740 106 967 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     intestinelarge intestinecolon highly
     liver   highly
     stomach   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY peptidase M1 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text small intestinal and renal microvillar membrane
    basic FUNCTION
  • playing a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic protease
  • important regulator of angiogenesis where its expression on activated blood vessels is induced by angiogenic signals
  • crucial mediator of galectin-3-induced angiogenesis in endothelial cells
  • receptor for one strain of human coronavirus
  • regulating tumor necrosis facto-alpha-induced apoptosis in neutrophils
  • regulating endothelial invasion and filopodia formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of Ras signaling in angiogenesis and is a limiting factor in angiogenic progression
  • interacting with LGALS3
  • cell & other
    REGULATION
    inhibited by PROL1
    Other transcription is regulated by the porot-oncogene c-Maf via an atypical response element
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS