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FLASH GENE
Symbol ANP32E contributors: mct - updated : 02-03-2016
HGNC name acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
HGNC id 16673
Location 1q21.2      Physical location : 150.190.717 - 150.208.504
Synonym name
  • leucine-rich acidic nuclear protein like
  • LANP- like protein
  • leucine-rich acidic nuclear protein like
  • Synonym symbol(s) MGC5350, LANPL, LANP-L, CPD1
    DNA
    TYPE functioning gene
    STRUCTURE 17.79 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3347 - 227 - 2002 12438741
    7 - 3470 - 268 - 2002 12438741
    7 - 3146 - 220 - 2002 12438741
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
     liver    
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N- terminal domain containing four leucine-rich repeats, LRR of 20-29 amino-acids containing a conserved 11 AA segment
  • a C-terminal low-compositional complexity acidic region
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to rattus anp32e (90 pc)
    ortholog to murine Anp32e (89 pc)
    intraspecies homolog to LANP
    Homologene
    FAMILY
  • leucine-rich repeats (LRR) superfamily
  • acidic nuclear phosphoprotein 32 (ANP32) family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • predominant presence of ANP32E in the nucleus
  • when is in the cytoplasm, it co-localizes spatially with protein phosphatase 2A (PPP2R4) near cell membranes, far from the synapses
  • basic FUNCTION
  • involved in the early development of brain
  • conserved role of members of the ANP32 family during evolution in the modulation of cell signalling and transduction of gene expression to regulate the morphology and dynamics of the cytoskeleton, cell adhesion, neural development or cerebellar morphogenesis
  • mediates potentially synaptogenesis process by modulating activity of PPP2R4
  • play potentially an important role in brain morphogenesis and synaptic development
  • it appears to play a role in the regulation of fine motor functions
  • ANP32A, ANP32B, ANP32E represent an important node of physiological regulation by virtue of their diverse biochemical activities
  • histone chaperone ANP32E removes H2AFZ from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • co-localizes, interacts and inhibits PPP2R4 activity, and phosphorylation of ANP32E is required for this interaction
  • H2AFZ removal from chromatin is likely the primary function of INO80 and ANP32E in promoting homologous recombination
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS