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Symbol ANP32C contributors: mct - updated : 03-03-2012
HGNC name acidic (leucine-rich) nuclear phosphoprotein 32 family, member C
HGNC id 16675
Location 4q32.2      Physical location : 165.118.159 - 165.118.863
Synonym name
  • phosphoprotein 32-related protein 1
  • tumorigenic protein pp32r1
  • Synonym symbol(s) PP32R1
    DNA
    TYPE functioning gene
    STRUCTURE 0.70 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure intronless
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 705 - 234 - 2005 15895553
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines prostatic adenocarcinoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a tandem arrays of a LRR, a structural motif implicated in the mediation of protein-protein interactions
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to Drosophila CG3961
    homolog to C.elegans Y65B4BL.5
    intraspecies homolog to PP32
    homolog to ANP32D
    Homologene
    FAMILY
  • acidic (leucine-rich) nuclear phosphoprotein 32 family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in transcriptional regulation, in differentiation, proliferation and thus tumorigenesis
  • conserved role of members of the ANP32 family during evolution in the modulation of cell signalling and transduction of gene expression to regulate the morphology and dynamics of the cytoskeleton, cell adhesion, neural development or cerebellar morphogenesis
  • with other ANP32 proteins have been implicated in a broad array of physiological processes, including cell differentiation, apoptotic cell death, and cell proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate and breast cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS