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FLASH GENE
Symbol ANP32B contributors: mct - updated : 23-02-2015
HGNC name acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
HGNC id 16677
Location 9q22.32      Physical location : 100.745.488 - 100.778.222
Synonym name
  • acidic protein rich in leucines
  • silver-stainable protein 29
  • Synonym symbol(s) APRIL, SSP29, PHAPI2, PAL31, PHAP1b
    DNA
    TYPE functioning gene
    STRUCTURE 32.74 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HABP4 9q22.3-q31 hyaluronan binding protein 4 CDC14B 9q22.32 CDC14 cell division cycle 14 homolog B (S. cerevisiae) C9orf21 9q22.32 chromosome 9 open reading frame 21 LOC286355 9q22.33 similar to hypothetical protein ZNF510 9q22.33 zinc finger protein 510 LOC158431 9q22.33 similar to zinc finger protein 11b (KOX 2) LOC347262 9q22.33 similar to hypothetical protein FLJ40432 LOC392369 9 similar to hypothetical protein HIATL2 9q22.33 hippocampus abundant gene transcript-like 2 CTSL2 9q22.2 cathepsin L2 TCEA1P 9q22.33 transcription elongation factor A (SII), 1 pseudogene LOC340508 9q22.33 hypothetical protein LOC340508 LOC389776 9 similar to RIKEN cDNA 2810453I06 LOC392370 9 similar to SNAG1 KIAA1529 9q22.33 KIAA1529 LOC389777 9 LOC389777 LOC286359 9q22.33 hypothetical protein LOC286359 PCTAIRE2BP 9q22.33 tudor repeat associator with PCTAIRE 2 TMOD1 9q22.32-q22.33 tropomodulin 1 LOC158427 9q22.33 PP4189 NCBP1 9q34.1 nuclear cap binding protein subunit 1, 80kDa XPA 9q22.32 xeroderma pigmentosum, complementation group A LOC392371 9 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) FOXE1 9q22.3 forkhead box E1 (thyroid transcription factor 2) NAP1 19q13.33 pronapsin A HEMGN 9q22.33 hemogen ANP32B 9q22.32 acidic (leucine-rich) nuclear phosphoprotein 32 family, member B NANS 9p24.1-p23 N-acetylneuraminic acid synthase (sialic acid synthase) TRIM14 9q22.32 tripartite motif-containing 14 CORO2A 9q22.3 coronin, actin binding protein, 2A TBC1D2 9q22.33 TBC1 domain family, member 2 GPR51 9q22.1 G protein-coupled receptor 51 SAMD6 9q31.1 sterile alpha motif domain containing 6 GALNT12 9q22.33 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12) LOC392372 9 similar to Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (P18) COL15A1 9q22.32-q22.33 collagen, type XV, alpha 1 TGFBR1 9q22 transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) ALG2 9q31.1 asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase) SEC61B 9q22.32-q31.3 asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase) LOC347265 9q31.1 similar to bA13B9.3 (novel protein similar to KRT8)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 1617 28.8 251 - 1998 9473664
    PHAPI2a
    - splicing 1290 - 195 - 1998 9473664
    - - - - - localize in the nucleus 2015 25483709
  • uncleavable mutant
  • CASP3&
  • 8209;resistant uncleavable ANP32B(D163A) is hypothesized to be pro&8209;apoptotic in leukemic cells
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart   highly
    Digestiveliver    
    Endocrinepancreas   highly
    Nervousbrain    
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Skin/Tegumentskin appendages    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialbarrier/lining   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text testis carcinoma and muscle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N terminal leucine rich repeats (LRR), that possesses histone chaperone activity and forms a curved structure with a parallel beta-sheet on the concave side and mostly helical elements on the convex side
  • C terminal acidic clusters, and variable anionic region, functioning as an inhibitor of histone acetylation
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Anp32b
    homolog to Drosophila CG3961
    homolog to C.elegans Y65B4BL.5
    Homologene
    FAMILY
  • acidic (leucine-rich) nuclear phosphoprotein 32 family
  • LRR subfamily
  • CATEGORY chaperone/stress , protooncogene , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • translocated partially to the nucleoli after heat shock
  • localize in the nucleus
  • basic FUNCTION
  • involved in antigen-mediated cellular responses, leukemogenesis and differentiation
  • participating in signal transduction directing nucleolar activities by regulating ribosomal RNA biosynthesis
  • shuttle phosphoprotein required for ELAVL1-mediated nucleocytoplasmic translocation of the CD83 mRNA by acting as an adaptor that links ELAVL1 and XPO1
  • novel substrate for caspase-3 and acts as a negative regulator for apoptosis
  • with other ANP32 proteins have been implicated in a broad array of physiological processes, including cell differentiation, apoptotic cell death, and cell proliferation
  • potential role for ANP32B in vascular development
  • inhibitory role of ANP32B against leukemic cell differentiation
  • potential role of ANP32B in regulating retinoic acid receptor signaling
  • ANP32A, ANP32B, ANP32E represent an important node of physiological regulation by virtue of their diverse biochemical activities
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to RNA polymerase 1
  • KLF5 interacts with the novel histone chaperone acidic nuclear phosphoprotein 32B (ANP32B), leading to transcriptional repression of a KLF5-downstream gene
  • histone chaperone that specifically bound to the transcription factor KLF5, leading to transcriptional repression of KLF5-downstream genes through inhibition of promoter histone acetylation
  • direct substrate of caspase-3 and it is primarily cleaved at the sequence of Ala-Glu-Val-Asp, after Asp-163
  • interaction of ANP32B with the core histones H3-H4 occurs on its concave side, and both the acidic and hydrophobic residues that compose the concave surface are critical for histone binding
  • direct substrate for CASP3 and acted as a negative regulator for leukemic cell apoptosis
  • might exert this role through inhibiting the all-trans retinoic acid (ATRA)dependent transcriptional activity of retinoic acid receptor (RARA)
  • TNFRSF13B binds the cytokines TNFSF13B and ANP32B
  • inhibit the expression of the anti&
  • 8209;apoptotic protein BCL2
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlates with shortened patient survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ANP32B mRNA expression in human breast cancers may serve as a prognostic marker
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    may serve as a potential therapeutic target for leukemia treatment
    ANIMAL & CELL MODELS
  • surviving Anp32b-deficient mice showed reduced viability due to variable defects in various organ systems