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FLASH GENE
Symbol ANP32A contributors: mct - updated : 05-11-2014
HGNC name acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
HGNC id 13233
Location 15q23      Physical location : 69.070.876 - 69.113.261
Synonym name
  • putative HLA class II associated protein I
  • cerebellar leucine rich acidic nuclear protein
  • mapmodulin
  • leucine-rich acid nuclear protein
  • inhibitor-1 of protein phosphatase-2A
  • potent heat-stable protein phosphatase 2A inhibitor I1PP2A
  • hepatic growth factor hepatopoietin Cn
  • Synonym symbol(s) LANP, PP32, PHAP1, PHAPI, C15orf1, I1PP2A, MAPM, MGC119787, MGC150373, HPPCn,
    DNA
    TYPE functioning gene
    STRUCTURE 41.02 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2479 - 249 - 2005 15895553
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Nervousbrainhindbraincerebellum   Homo sapiens
     brainforebraincerebral cortex   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    NervousPurkinje cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period perinatal
    Text highly in developing brain and postnatal (early weeks of life)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a leucine/isoleucine rich N terminal region
  • an extended highly acid C terminal region
  • LRR domains that might also provide basis for additional regulation of the cellular apoptotic activity of PHAPI
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Lanp
    intraspecies homolog to PHAPI highly
    homolog to DEK and SET
    homolog to SNRPU2A
    Homologene
    FAMILY
  • INHAT family of corepressors that inhibits histone acetyltransferases
  • acidic nuclear phosphoprotein 32 (ANP32) family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,nucleoplasm
    text
  • predominantly a nuclear protein, and it can translocate to the cytoplasm during apoptosis
  • nucleocytoplasmic shuttling protein with a diverse array of functions, including an ability to modulate the cytoskeletal compartment by binding to microtubule-associated proteins
  • prominently located within the nuclei of hepatocytes
  • basic FUNCTION
  • nucleoplasmic shuttling protein involved in several processes such as regulation of gene expression, RNA transport, apoptosis, intracellular signaling and cytoskeletal dynamics
  • protein-protein interactions, may be involved in signal transduction or in RNA processing
  • heat stable protein phosphatase 2A inhibitor
  • regulator of the apoptosis response of cancer cells and predictor of survival following chemotherapy for advanced non small cell lung cancer
  • apoptotic enhancer that stimulates apoptosome-mediated caspase activation
  • directly regulates expression of the neurofilament light chain, an important neuron-specific cytoskeletal gene, by binding to the promoter of this gene and modulating histone acetylation levels
  • nuclear protein with the ability to promote liver regeneration
  • is potentially involved in the formation of IFN-stimulated genes (ISGs) transcription initiation complexes, possibly as their recruiter
  • with other ANP32 proteins have been implicated in a broad array of physiological processes, including cell differentiation, apoptotic cell death, and cell proliferation
  • mediates neuritic pathology in Spinocerebellar ataxia type 1
  • attenuated oxidative injury and fibrosis induced by ethanol feeding and the SPHK1/S1P/S1PRs signalling pathway contributes to the protective effect of HPPCn on hepatocyte apoptosis
  • ANP32A, ANP32B, ANP32E represent an important node of physiological regulation by virtue of their diverse biochemical activities
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • complexing with transcriptional repressor E4F1 and modulates its activity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ataxin 1 (ATXN1), modulates repression induced by ANP32A
  • directly associates with the promoter of the NEFL gene and regulates the acetylation of histones in the vicinity of the NEFL promoter
  • is a novel molecular target of sphingoid bases that regulates cellular signaling events and inflammatory gene expression
  • can interact with RB1 in both young and mature neurons and is implicated in the regulation of neuronal survival by CXCL12/CXCR4
  • interacted with signal transducer and activator of transcription 1 (STAT1) and STAT2 in an IFN-dependent manner
  • ANP32A is a PPP2R4 endogenous inhibitor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    involved in the neoplasia
    tumoral     --over  
    in hepatocellular carcinoma and significantly associated with poor tumor cellular differentiation and present of vascular invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be involved in the development of hepatocellular carcinoma (HCC) and could be served as a promising biomarker
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyataxia 
    depleting ANP32A-an ATXN1 binding inhibitor of histone acetylation-reverses aspects of SCA1 neuritic pathology
    cancer  
    promising target for cancer treatment
    ANIMAL & CELL MODELS