basic FUNCTION
| constitutes the olfactory calcium-activated chloride channel |
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constitutes the long-sought olfactory calcium-activated chloride channel (CaCC) that may mediate signal amplification |
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playing a role in olfactory signal transduction |
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and might also play roles in other neuronal systems |
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may be functioning as Ca(2+)-activated Cl(-) channels |
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provides a ciliary pathway for the excitatory chloride current |
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ANO6 is an essential component of a Ca(2+)-activated Cl(-) channel with a Ca(2+) sensitivity that is distinct from that of ANO1/ANO2 and that it is not related to volume-sensitive outwardly rectifying Cl(-) channel (VSOR) activity |
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ANO1 and ANO2 regulate diverse processes including mucus secretion, neuronal excitability, smooth muscle contraction, olfactory signal transduction, and cell proliferation |
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involved in a Ca2+-dependent regulation of synaptic weight in GABAergic inhibition |
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ANO1, and ANO2 are plasma membrane proteins with Ca2+-dependent Cl- channel function |