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FLASH GENE
Symbol ANO2 contributors: mct - updated : 23-03-2016
HGNC name anoctamin 2
HGNC id 1183
Location 12p13.31      Physical location : 5.671.816 - 6.055.398
Synonym name
  • chromosome 12 open reading frame 3
  • transmembrane protein 16B
  • transmembrane protein 16B (eight membrane-spanning domains)
  • Synonym symbol(s) C12orf3, TMEM16B, DKFZp434P102
    DNA
    TYPE functioning gene
    STRUCTURE 383.58 kb     27 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 3735 113 998 - 2004 15067359
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Nervousbraindiencephalonepithalamuspineal gland 
     brainhindbraincerebellumcerebellar cortex  Homo sapiens
     nervecranial nerveolfactory nerve highly Homo sapiens
    Visualeyeretina  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    NervousPurkinje cell Homo sapiens
    Olfactoryolfactory receptor Homo sapiens
    Visualcone photoreceptor
    Visualrod photoreceptor
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight membrane-spanning domains
  • a consensus PDZ class I binding motif capable of interacting with PDZ domains of DLG4
  • both N and C termini in the cytoplasm, a topology consistent with many ion channels
  • HOMOLOGY
    interspecies homolog to Drosophila CG2789
    homolog to murine Tmem16b
    intraspecies paralog to ANO1
    Homologene
    FAMILY
  • anoctamin family
  • Calcium-activated chloride channels family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • colocalizes with adaptor proteins DLG4, LIN7C, and MPP4 at the ribbon synapses
  • specifically expressed in the cilia of olfactory sensory neurons
  • ANO1 appeared to be retained in the cell body, ANO2 was targeted to the dendritic tree (
  • basic FUNCTION
  • constitutes the olfactory calcium-activated chloride channel
  • constitutes the long-sought olfactory calcium-activated chloride channel (CaCC) that may mediate signal amplification
  • playing a role in olfactory signal transduction
  • and might also play roles in other neuronal systems
  • may be functioning as Ca(2+)-activated Cl(-) channels
  • provides a ciliary pathway for the excitatory chloride current
  • ANO6 is an essential component of a Ca(2+)-activated Cl(-) channel with a Ca(2+) sensitivity that is distinct from that of ANO1/ANO2 and that it is not related to volume-sensitive outwardly rectifying Cl(-) channel (VSOR) activity
  • ANO1 and ANO2 regulate diverse processes including mucus secretion, neuronal excitability, smooth muscle contraction, olfactory signal transduction, and cell proliferation
  • involved in a Ca2+-dependent regulation of synaptic weight in GABAergic inhibition
  • ANO1, and ANO2 are plasma membrane proteins with Ca2+-dependent Cl- channel function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • novel component of a presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors
  • ANO1, ANO2 are subunits of Ca2 activated Chlore channel (CaCC)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a number of tumours and functional deficiency in others is linked to developmental defects
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • promising candidate for the olfactory calcium-activated chloride channel
  • strong candidate for the long sought-after Ca(2+)-dependent chloride channel in the photoreceptor synapse
  • Marker
    Therapy target
    ANIMAL & CELL MODELS