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FLASH GENE
Symbol ANLN contributors: mct - updated : 13-09-2014
HGNC name anillin, actin binding protein
HGNC id 14082
Corresponding disease
FSGS7 focal segmental glomerulosclerosis 7
Location 7p14.2      Physical location : 36.429.431 - 36.493.398
Synonym symbol(s) LOC54443, ANILLIN, SCRAPS, Scrap, scra
DNA
TYPE functioning gene
STRUCTURE 63.99 kb     24 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC392794 7 similar to HWKM1940 LOC222128 7p14.2 similar to hypothetical protein FLJ32949 LOC389479 7 similar to hypothetical protein FLJ32949 MTPN 7q33-q35 myotrophin TBX20 7p15-p14 T-box 20 FLJ22313 7p14.2 hypothetical protein FLJ22313 CDC10 7p14.3-p14.1 CDC10 cell division cycle 10 homolog (S. cerevisiae) LOC392884 7 similar to cell division cycle 10 homolog FLJ22313 7p14.2 hypothetical protein FLJ22313 KIAA1706 7p14 KIAA1706 protein CDC10 7p14.3-p14.1 CDC10 cell division cycle 10 homolog (S. cerevisiae) LOC392014 7 similar to cell division cycle 10 homolog KIAA0895 7p14.1 KIAA0895 protein LOC392996 7 similar to protease (prosome, macropain) 26S subunit, ATPase 1 ANLN 7p15-p14 anillin, actin binding protein (scraps homolog, Drosophila) KIAA1706 7p14 KIAA1706 protein AOAH 7p14-p12 acyloxyacyl hydrolase (neutrophil) LOC392795 7 LOC392795 CHRM2 7q31-q35 cholinergic receptor, muscarinic 2 KIAA0895 7p14.1 KIAA0895 protein LOC392796 7 LOC392796 ANLN 7p15-p14 anillin, actin binding protein (scraps homolog, Drosophila) LOC392885 7 similar to nucleophosmin/B23.2 ELMO1 7p14.3-p14.1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) PTN 7q33-q34 pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) AOAH 7p14-p12 acyloxyacyl hydrolase (neutrophil) DGKI 7q32.3-q33 diacylglycerol kinase, iota NPM1P18 7p14.1 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 18 ELMO1 7p14.3-p14.1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) CREB3L2 7q33-q34 cAMP responsive element binding protein 3-like 2 LOC392886 7 similar to DKFZP566B183 protein AKR1D1 7q32-q33 aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) GPR141 7p14.1 G protein-coupled receptor 141 TXNDC3 7p15.2 thioredoxin domain containing 3 (spermatozoa) SFRP4 7p14.1 secreted frizzled-related protein 4 UCC1 7p14.1 secreted frizzled-related protein 4 LOC392997 7 similar to dJ753D5.2 (novel protein similar to RPS17 (40S ribosomal protein S17)) LOC340285 7p14.1 similar to DKFZP566B183 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
24 - 4801 124 1124 - 2008 18158243
23 - 4690 - 1087 - 2008 18158243
23 - 4687 - 1086 - 2008 18158243
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Nervousbrain   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved N-terminal actin and myosin binding domains and
  • a pleckstrin homology (PH) domain at the C terminus, conserved C-terminal domain that is essential for its function and localization
  • HOMOLOGY
    interspecies homolog to Anilin
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • playing a role in cytokinesis
  • septin assembly and septum formation
  • may be playing a significant role in pulmonary carcinogenesis
  • having nonproliferation-associated activities and roles in interphase nuclei
  • substrate of the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that controls mitotic progression
  • is required to maintain active myosin in the equatorial plane during cytokinesis, suggesting it functions as a scaffold protein to link RHOA with the ring components actin and myosin
  • functioning to maintain the localization of active myosin, thereby ensuring the spatial control of concerted contraction during cytokinesis
  • an ANLN-ECT2 complex stabilizes central spindle microtubules at the cortex during cytokinesis
  • F-actin binding cell cycle gene
  • is important in maintaining the integrity of the podocyte actin cytoskeleton
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin
  • actin-binding protein that can bind septins
  • interaction between DIAPH2 and ANLN is required for the localization and function of DIAPH2 in cytokinesis
  • CIT is capable of physically and functionally interacting with the actin-binding protein ANLN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FSGS7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung carcinoma, in breast, ovarian, kidney, colorectal, hepatic, endometrial, and pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • NBL1 and ANLN are promising markers for pancreatic carcinoma molecular diagnostics
  • Therapy target
    ANIMAL & CELL MODELS