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FLASH GENE
Symbol ANKRD42 contributors: mct/npt - updated : 03/01/2009
HGNC name ankyrin repeat domain 42
HGNC id 26752
Location 11q14.1      Physical location : 82.905.290 - 82.960.013
Synonym name several ankyrin repeat protein
Synonym symbol(s) FLJ37874, SARP
DNA
TYPE functioning gene
STRUCTURE 54.72 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2562 43 389 - Browne (2007)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion sperm
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 23 ANK repeats
  • a death domain
  • a ZU5 domain
  • HOMOLOGY
    Homologene
    FAMILY
  • ankyrin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text cytoplasmic surface of erythrocytic plasma membrane
    basic FUNCTION
  • attach integral membrane proteins to cytoskeletal elements
  • may be transcription factor or DNA-associated protein that modulate gene expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding SPTB/spectrin (beta chain) through a 70 aa N-terminal region of the 62 kda domain, and the C-terminal of SLC14A1/erythrocyte membrane protein band 3 through the anykrin repeat region
  • interacting with protein phosphatase 1 (interaction motif lies partially within the first ankyrin repeat)
  • cell & other
    REGULATION
    Other regulated by phosphorylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS