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FLASH GENE
Symbol ANKRD12 contributors: mct/npt - updated : 26-09-2009
HGNC name ankyrin repeat domain 12
HGNC id 29135
Location 18p11.22      Physical location : 9.136.757 - 9.285.206
Synonym name
  • GAC-1 protein
  • ankyrin repeat-containing cofactor 2
  • Synonym symbol(s) GAC-1, ANCO-2, FLJ20053, KIAA0874, ANCO1, ANCO2, Nbla00144
    DNA
    TYPE functioning gene
    STRUCTURE 148.45 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 splicing 10528 235 2062 - Li (2008)
    12 splicing 10459 233 239 - Zhang (2004), Li (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five ankyrin repeats
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text colocalized with histone deacetylases
    basic FUNCTION
  • may be recruiting HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the PAS region of the p160 coactivators
  • interacting with histone deacetylases
  • also interact with the co-activator TADA3L (repress TADA3L-mediated transcriptional co-activation on nuclear receptors) (Li 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS