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FLASH GENE

Symbol

ANGPTL5

contributors: mct - updated : 06-06-2016

HGNC name	angiopoietin-like 5
HGNC id	19705

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q22.1      Physical location : 101.761.405 - 101.787.253
Synonym name	fibrinogen-like

DNA

TYPE	functioning gene
STRUCTURE	26.04 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_178127 9 - 2383 NP_835228 - 388 - 2003 12624729

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Homo sapiens Adult Nervous brain diencephalon hypothalamus       nerve       highly Urinary bladder       highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol nervous dorsal root ganglia

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal 25 aa cleavable signal peptide
	a predicted coiled-coil domain
	a fibrinogen-like domain

conjugated

GlycoP

isoforms

Precursor

a 363 aa mature proteine

HOMOLOGY

interspecies

homolog to chicken angptl5

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	inducing sprouting in endothelial cells through an autocrine and paracrine action
	ANGPTL3, ANGPTL4, and ANGPTL5, but not ANGPTL6, play nonredundant roles in triglyceride metabolism
	ANGPTL3, ANGPTL4, and possibly ANGPTL5 are regulators of lipoprotein metabolism
	ANGPTL4 and ANGPTL5 can lead to increased engraftment capacity of NOD/SCID-repopulating cells (SRCs)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ANGPTL5 supports expansion of human cord blood hematopoietic stem cells in a process at least partially mediated by the surface receptor LILRB2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS