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FLASH GENE
Symbol ANGPTL1 contributors: npt - updated : 04-04-2006
HGNC name angiopoietin-like 1
HGNC id 489
Location 1q25.2      Physical location : 178.818.670 - 178.840.215
Synonym name
  • angiopoietin 3
  • angiopoietin Y1
  • angioarrestin
  • Synonym symbol(s) ANG3, ANGY, ARP1, ANGPT3, UNQ162, KIAA0351, UNQ162/PRO188, dJ595C2.2
    DNA
    TYPE functioning gene
    STRUCTURE 21.00 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388716 1 LOC388716 COP1 1q24.2 constitutive photomorphogenic protein LOC391140 1 similar to 60S ribosomal protein L13 (A52) PLAC3 1q23-q25 placenta-specific 3 ASTN 1q25.2 astrotactin LOC57795 1q24.1-q25.3 hypothetical protein from clone 24828 RGPR 1q24.2-q25.2 hypothetical protein from clone 24828 LOC391141 1 similar to Quinone oxidoreductase (NADPH:quinone reductase) (Zeta-crystallin) RASAL2 1q25 RAS protein activator like 2 DKFZP564J047 1q24.3 hypothetical protein DKFZp564J047 FLJ10244 1q24.3 Ral-A exchange factor RalGPS2 ANGPTL1 1q24.2 angiopoietin-like 1 FAM20B 1q25 family with sequence similarity 20, member B TOR3A 1q24.2-q24.3 torsin family 3, member A ABL2 1q24-q25 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) SOAT1 1q25 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 FLJ32940 1q24.3 hypothetical protein FLJ32940 NPHS2 1q25-q31 nephrosis 2, idiopathic, steroid-resistant (podocin) LOC126860 1q24.3 similar to centaurin, gamma 2 TDRD5 1q24.2 tudor domain containing 5 MGC16664 1q25.1 hypothetical protein MGC16664 LOC163590 1q25.1 AF464140 IFRG15 1q25.1 IFRG15 protein LAP1B 1q24.2 lamina-associated polypeptide 1B CAP350 1p36.13-q41 lamina-associated polypeptide 1B QSCN6 1q24 quiescin Q6 FLJ23867 1q25.1 hypothetical protein FLJ23867 LHX4 1q24.1-q24.3 LIM homeobox 4 LOC388717 1 LOC388717 ACBD6 1q25.1 acyl-Coenzyme A binding domain containing 6 XPR1 1q25 xenotropic and polytropic retrovirus receptor KIAA1614 1q25.1 KIAA1614 protein LOC391142 1 hypothetical gene supported by AJ249778; NM_001531 STX6 1p36 syntaxin 6 MR1 1q25.3 major histocompatibility complex, class I-related IER5 1q25.1 immediate early response 5 LOC284646 1q25.1 hypothetical gene supported by BC039493 CACNA1E 1q25-q31 calcium channel, voltage-dependent, alpha 1E subunit
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3555 56.7 491 - Kim
    - - 4000 - - - Kim
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
     vessel   highly
    Digestiveintestinesmall intestine  highly
     pancreas exocrine   moderately
    Endocrineadrenal gland   moderately
     parathyroid   highly
     thyroid   highly
    Lymphoid/Immunelymph node   predominantly
    Nervousnerve   moderately
    Reproductivefemale systemuterus  highly
     male systemtestis  moderately
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Epithelialbarrier/liningendothelium  
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumcardiac  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal, pregnancy
    Text placenta highly, umbilical cord moderately
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a 21 aa signal peptide
  • a N-terminal coiled-coil domain as well as a highly hydrophobic region
  • a C-terminal fibrinogen-like domain
  • several potential glycosylation sites
  • calcium binding motif
  • conjugated GlycoP
    isoforms Precursor a mature form of 470 aa for 54.3 kda
    HOMOLOGY
    interspecies homolog to murine Angptl1
    intraspecies homolog to ANGPT1
    homolog to ANGPT2
    homolog to ANGPTL2
    Homologene
    FAMILY
  • vascular endothelial growth factor family
  • angiopoietin family
  • CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as an anti-angiogenic molecule
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS