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FLASH GENE
Symbol ANGPT4 contributors: - updated : 07-04-2006
HGNC name angiopoietin 4
HGNC id 487
Location 20p13      Physical location : 853.298 - 896.960
Synonym name angiopoietin 3
Synonym symbol(s) ANG4, ANG-3, AGP4
DNA
TYPE functioning gene
STRUCTURE 43.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
C20orf99 20p13-p12.2 chromosome 20 open reading frame 99 SOX12 20p13 SRY (sex determining region Y)-box 12 C20orf98 20p13 chromosome 20 open reading frame 98 C20orf97 20p12.2-p13 chromosome 20 open reading frame 97 C20orf18 20p13 chromosome 20 open reading frame 18 C20orf140 20p13 chromosome 20 open reading frame 140 CSNK2A1 20p13 casein kinase 2, alpha 1 polypeptide TCF15 20p13 transcription factor 15 (basic helix-loop-helix) C20orf139 20p13 chromosome 20 open reading frame 139 LOC391226 20 similar to dJ850E9.1 (novel C2H2 type zinc finger protein similar to Drosophila Scratch (Scrt), Slug and Xenopus Snail) C20orf54 20p13 chromosome 20 open reading frame 54 RPS10L 20p13 ribosomal protein S10-like C20orf55 20p13 chromosome 20 open reading frame 55 ANGPT4 20p13 angiopoietin 4 LOC343637 20p13 similar to dJ824F16.3 (novel protein similar to mouse thrombospondin type 1 domain protein R-spondin) PSMF1 20p13-p12.2 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) ACTGP3 20p13 actin, gamma pseudogene 3 C20orf46 20p13 chromosome 20 open reading frame 46 SNPH 20p13 syntaphilin SDCBP2 20p13 syndecan binding protein (syntenin) 2 FLJ20802 20p13 hypothetical protein FLJ20802 FKBP1A 20p13 FK506 binding protein 1A, 12kDa
RNA
TRANSCRIPTS type messenger
text a major 5- and a minor 4-kb transcript (Valenzuela, 1999)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung   predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • an N terminal region lacking homology to any known structure
  • a fibrinogen-like domain at the C terminus
    • secondary structure
  • an alpha-helical rich coiled-coil segment
    • isoforms Precursor a 479 aa mature peptide
    HOMOLOGY
    interspecies homolog to murine Angpt4
    homolog to rattus Agpt4
    intraspecies homolog to ANGTP1
    homolog to ANGPT2
    Homologene
    FAMILY
  • vascular endothelial growth factor family
  • angiopoietin family
    • CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • secreted ligand for the vascular endothelial restricted receptor tyrosine kinase TEK, including phosphorylation of TEK
  • promoting angiogenic remodeling as well as vessel maturation and stabilization
  • activating tyrosine-protein kinase receptor tie 2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component Binds to tyrosine-protein kinase receptor TIE2 and activates it
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • tyrosine-protein kinase receptor tie 2
    • cell & other
    REGULATION
    repressed by vascular endothelial cell growth factor
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS