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FLASH GENE
Symbol ANAPC7 contributors: mct - updated : 03-09-2010
HGNC name anaphase-promoting complex subunit 7
HGNC id 17380
Location 12q24.11      Physical location : 110.810.704 - 110.841.535
Synonym name cyclosome subunit 7
Synonym symbol(s) APC7
DNA
TYPE functioning gene
STRUCTURE 30.83 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3070 - 599 - Yu (1998)
10 - 2224 - 537 - Yu (1998)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselaorta   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • multiple copies of the tetratrico peptide repeat
  • HOMOLOGY
    interspecies homolog to murine Anapc7
    Homologene
    FAMILY
  • APC7 (anaphase-promoting complex) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • controlling progresion through anaphase by triggering the degradation of cell cycle regulators such securin and B-type cyclin
  • suppressing E1A-mediated transformation in a CBP/p300-dependent manner
  • orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains (Jin 2008)
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, progression
    PHYSIOLOGICAL PROCESS
    text ubiquitin dependent catabolism
    PATHWAY
    metabolism
    signaling
    a component
  • member of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting directly with the coactivators CBP and p300 through protein-protein interaction domains that are evolutionary donserved in adenovirus E1A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS