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FLASH GENE
Symbol ANAPC2 contributors: mct - updated : 03-09-2010
HGNC name anaphase promoting complex subunit 2
HGNC id 19989
Location 9q34.3      Physical location : 140.069.235 - 140.083.057
Synonym name
  • anaphase-promoting complex/cyclosome
  • cyclosome subunit 2
  • Synonym symbol(s) APC2, KIAA1406, RP11-350O14.5
    DNA
    TYPE functioning gene
    STRUCTURE 13.82 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC15438 9q34.3 hypothetical protein MGC15438 FLJ10101 9q34.3 FLJ10101 protein LOC389813 9 similar to ENSANGP00000006371 PHP14 9q34.3 phosphohistidine phosphatase AEGP 9q34.3 apical early endosomal glycoprotein precursor EDF1 9q34.3 endothelial differentiation-related factor 1 TRAF2 9q34 TNF receptor-associated factor 2 FBXW5 9q34.3 F-box and WD-40 domain protein 5 C8G 9q22.33-q32 complement component 8, gamma polypeptide MGC48935 9q34.3 hypothetical protein MGC48935 LOC203235 9q34.3 hypothetical LOC203235 PTGDS 9q34.2-q34.3 prostaglandin D2 synthase 21kDa (brain) LOC286257 9q34.3 hypothetical protein LOC286257 CLIC3 9q34.3 chloride intracellular channel 3 ABCA2 9q34.3 ATP-binding cassette, sub-family A (ABC1), member 2 FUT7 9q34.3 fucosyltransferase 7 (alpha (1,3) fucosyltransferase) LOC389814 9 similar to LPAL6438 NPDC1 9q34.3 neural proliferation, differentiation and control, 1 ENTPD2 9q34 ectonucleoside triphosphate diphosphohydrolase 2 LOC89958 9q34.3 hypothetical protein LOC89958 LOC91373 MAN1B1 9q34 mannosidase, alpha, class 1B, member 1 DPP7 9q34.3 dipeptidylpeptidase 7 LOC389815 9 LOC389815 GRIN1 9q34.3 glutamate receptor, ionotropic, N-methyl D-aspartate 1 LOC389816 9 similar to CDNA sequence BC004853 LOC389817 9 LOC389817 ANAPC2 9q34.3 LOC389817 SSNA1 9q34.3 Sjogren's syndrome nuclear autoantigen 1 C9orf75 9q34.3 chromosome 9 open reading frame 75 MGC14327 9q34.3 hypothetical protein MGC14327 NELF 9q34.3 nasal embryonic luteinizing hormone-releasing hormone factor FLJ43070 9q34.3 FLJ43070 protein MRPL41 9q34.3 mitochondrial ribosomal protein L41 LOC92715 9q34.3 hypothetical protein BC017335 ZMYND19 9q34.3 zinc finger, MYND domain containing 19 MGC40555 C9orf37 9q34.3 chromosome 9 open reading frame 37
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2733 - 822 - Yu (1998)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Nervousbraindiencephalonhypothalamus  
     braindiencephalonamygdala  
     nerve   highly
    Reproductivefemale systemovary   
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C terminal cullin homology domain
  • HOMOLOGY
    Homologene
    FAMILY
  • cullin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • controlling progresion through anaphase by triggering the degradation of cell cycle regulators such securin and B-type cyclin
  • involved in regulation of axonal growth and synaptic functions in postmitotic neurons
  • orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains (Jin 2008)
  • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ubiquitin dependent catabolism
    a component
  • member of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inversin (interaction dependent on a conseved D-box motif)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS