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FLASH GENE
Symbol ANAPC13 contributors: mct - updated : 03-09-2010
HGNC name anaphase promoting complex subunit 13
HGNC id 24540
Location 3q22.2      Physical location : 134.196.546 - 134.204.865
Synonym name
  • homolog of yeast Swm1
  • cyclosome subunit 13
  • Synonym symbol(s) SWM1, APC13, DKFZP566D193
    DNA
    TYPE functioning gene
    STRUCTURE 8.32 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1219 - 74 - Schwickart (2004)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivegallbladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Anapc13
    Homologene
    FAMILY
  • APC (anaphase promoting complex) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • promotes the stable association with the APC/C of the essential subunits CDC16 and CDC27
  • is required for the timely execution of APC/C-dependent cell cycle events
  • orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains (Jin 2008)
  • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    text mitotic checkpoint regulator
    PATHWAY
    metabolism
    signaling
    a component
  • component of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS