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FLASH GENE
Symbol ANAPC10 contributors: mct - updated : 03-09-2010
HGNC name anaphase promoting complex subunit 10
HGNC id 24077
Location 4q31.21      Physical location : 145.916.313 - 146.019.368
Synonym name cyclosome subunit 10
Synonym symbol(s) DOC1, DKFZP564L0562, APC10
DNA
TYPE functioning gene
STRUCTURE 103.06 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 885 - 185 - Grossberger (1999)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DOC domain
  • HOMOLOGY
    interspecies homolog to Drosophila CG11419
    ortholog to yeast S.cerevisiae Doc1/Apc10
    Homologene
    FAMILY
  • APC10 (anaphase promoting complex) family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text localized in centrosomes and mitotic spindles throughout mitosis
  • localized in kinetochores from prophase to anaphase and in midbody in telophase and cytokinesis
  • basic FUNCTION
  • controlling progresion through anaphase by triggering the degradation of cell cycle regulators such securin and B-type cyclin
  • orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains (Jin 2008)
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, progression
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    text regulation of cell cycle
    PATHWAY
    metabolism other
    signaling
    ubiquitin-dependent protein catabolism
    a component
  • member of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS