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FLASH GENE

Symbol

AMZ1

contributors: mct - updated : 23-03-2020

HGNC name	archaelysin family metallopeptidase 1
HGNC id	22231

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7p22.3      Physical location : 2.719.162 - 2.755.069
Synonym name	metalloproteinase-like protein
	archaemetzincin-1
	archeobacterial metalloproteinase-like protein 1
Synonym symbol(s)	KIAA1950
EC.number	3.-.-.-

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	85.67 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_133463 7 - 6531 NP_597720 55 498 - 2013 23563607 NM_001321766 7 - 1675 NP_001308695 - 330 - 2013 23563607 NM_001284355 6 - 5291 NP_001271284 - 297 - 2013 23563607

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Skin/Tegument skin         Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a catalytic domain with a core motif (HEXXHXXGX3CX4CXMX17CXXC) that includes an archetypal zinc-binding site
	the methionine residue characteristic of metzincins
	four conserved cysteine residues that are not present at the equivalent positions of other metalloproteases

conjugated

PhosphoP

HOMOLOGY

Homologene

FAMILY

archaemetzincin family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION

functional protease activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS