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FLASH GENE
Symbol AMTN contributors: mct - updated : 30-08-2021
HGNC name amelotin
HGNC id 33188
Corresponding disease
AI3B amelogenesis imperfecta, type IIIB
Location 4q13.3      Physical location : 71.384.297 - 71.398.459
Synonym symbol(s) UNQ689, MGC148132, MGC148133, AI3B
DNA
TYPE functioning gene
STRUCTURE 14.17 kb     9 Exon(s)
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1009 - 209 - Moffatt (2006)
9 - 1006 - 208 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtoothenamel  
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningretinal pigment epithelium (RPE)   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveameloblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION extracellular
plasma membrane,junction
    intracellular
intracellular,cytoplasm,organelle,lumen
intracellular,cytoplasm,organelle,endoplasmic reticulum
text localized to the basal lamina of maturation stage ameloblasts of incisors and unerupted molars
  • localized at the interface between the enamel surface and the apical surface of ameloblasts
  • basic FUNCTION
  • plays a critical role in the formation of dental enamel
  • may be playing a role in cell adhesion
  • factor produced by ameloblasts that plays a critical role in the formation of dental enamel
  • is a recently discovered secreted enamel protein predominantly expressed during the maturation stage of enamel formation
  • distinct expression of AMTN and ODAM and their interaction are likely involved in defining the enamel microstructure at the enamel surface
  • AMTN and ODAM, participates in structuring the basal lamina and in mediating attachment of epithelia cells to mineralised tooth surfaces
  • critical role for AMTN in the formation of the compact aprismatic enamel surface layer during the maturation stage of amelogenesis
  • AMTN and KLK4 function independently, but are both necessary for proper enamel maturation
  • AMTN, and ODAM participate in structuring an extracellular matrix with the distinctive capacity of attaching epithelial cells to mineralized surfaces
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AMTN interacts with itself and with ODAM, but not with amelogenin (AMELX), ameloblastin (AMBN), or enamelin (ENAM)
  • IL1B increases AMTN gene transcription in gingival epithelial cells mediated through CEBP1, CEBP2, and YY1 elements in the human AMTN gene promoter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AI3B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS