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FLASH GENE
Symbol AMOTL2 contributors: mct - updated : 09-09-2015
HGNC name angiomotin like 2
HGNC id 17812
Location 3q22.2      Physical location : 134.074.189 - 134.093.406
Synonym name
  • Leman coiled-coil protein
  • MAGI-1-associated coiled-coil tight junction protein
  • angiomotin-like protein 2
  • Synonym symbol(s) LCCP, KIAA0989, MASCOT
    DNA
    TYPE functioning gene
    STRUCTURE 19.22 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4984 - 780 - 2007 17397395
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain   highly
     nerve   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a polyglutamic acid repeat at the N-terminal region
  • a coiled-coil domain
  • a consensus motif for binding to PDZ domain at the C terrminus, C-terminal PDZ-binding motifs, required for the interactions with AMOTL1, AMOT, MPDZ, and INADL
  • HOMOLOGY
    interspecies homolog to murine Amotl2
    homolog to C.elegans C15B12.1
    Homologene
    FAMILY
  • motins family
  • Amot/JEAP family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text
  • peripheral membrane proteins
  • apparent at TJs as well as apical membranes, and mostly co-localized with MPDZ
  • LATS2, AMOTL2, and YAP1 all localize to tight junctions, raising the possibility that clustering of Hippo pathway components at tight junctions might function to trigger LATS2 activation and growth inhibition in response to increased cell density
  • basic FUNCTION
  • involved in the control of paracellular permeability and maintain cell polarity
  • mediates the inhibitory effect of angiostatin on endothelial cell migration and tube formation
  • AMOTL1 and AMOTL2 can regulate YAP1 cytoplasm-to-nucleus translocation through direct protein-protein interaction, which can occur independent of YAP1 phosphorylation status
  • AMOT, AMOTL1 and AMOTL2, play critical roles in the Hippo pathway by regulating the subcellular localization of the co-activators YAP1 and TAZ
  • role for AMOTL2 in synaptic maturation, supporting the involvement of podosomes in this process
  • scaffold protein AMOTL2 is needed for aortic vessel lumen expansion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of tight junction
  • AMOTL2/CDH5 complex is responsible for transmitting mechanical force between endothelial cells for the coordination of cellular morphogenesis consistent with aortic lumen expansion and function
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacing with MPDZ and INADL (interaction not necessarily responsible for their proper subcellular distribution)
  • AMOTL1 and AMOTL2, are YAP1-associated proteins
  • novel activator of LATS2 (binds MST2, LATS2, and YAP1, suggesting that AMOTL2 might serve as a scaffold protein)
  • three regulators of the actin cytoskeleton--AMOTL2, SPATA13 and FLII--interact with PHLDB2 (pMID: 23525008
  • cell & other
    REGULATION
    Other regulated by NUDT16 (like DCP2, NUDT16 regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis, Angiomotin-like 2 (AMOTL2)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS