Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AMN contributors: mct - updated : 12-12-2018
HGNC name amnionless homolog (mouse)
HGNC id 14604
Corresponding disease
MGA1 megaloblastic anemia 1
Location 14q32.3      Physical location : 103.388.992 - 103.397.178
Synonym name visceral endoderm-specific type 1 transmembrane protein
Synonym symbol(s) PRO1028
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status
Physical map
RAGE 14q32 renal tumor antigen C14orf131 14q32.33 chromosome 14 open reading frame 131 CINP 14q32.33 cyclin-dependent kinase 2-interacting protein KIAA0329 14q32-.11 cyclin-dependent kinase 2-interacting protein ANKRD9 14q32.33 ankyrin repeat domain 9 LOC283604 14q32.33 hypothetical LOC283604 RCOR 14q32.32 REST corepressor RPL23AP11 14 ribosomal protein L23a pseudogene 11 TRAF3 14q32.3 TNF receptor-associated factor 3 AMN 14q32.3 amnionless homolog (mouse) CDC42BPB 14q32.3 CDC42 binding protein kinase beta (DMPK-like) C14orf73 14 chromosome 14 open reading frame 73 TNFAIP2 14q32 tumor necrosis factor, alpha-induced protein 2 RPL21P12 14q32.33 ribosomal protein L21 pseudogene 12 RPL21P13 14 ribosomal protein L21 pseudogene 13 RPL17P4 14 ribosomal protein L17 pseudogene 4 LOC388019 14 LOC388019 EIF5 14q32.33 eukaryotic translation initiation factor 5 LAMR1P5 14 laminin receptor 1 pseudogene 5 MARK3 14q32.3 MAP/microtubule affinity-regulating kinase 3 RPL10AP1 14 ribosomal protein L10a pseudogene 1 CKB 14q32.32 creatine kinase, brain FLJ40452 14q32.33 hypothetical protein FLJ40452
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestinecolon highly
Respiratorylung    
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one VWFC domain
conjugated GlycoP
isoforms Precursor
HOMOLOGY
interspecies ortholog to murine Amn
homolog to rattus Amn
Homologene
FAMILY
CATEGORY receptor membrane
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • modulating bone morphogenetic protein (BMP) receptor function, serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding
  • necessary for efficient absorption of vitamin B12
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functioning in the same pathway as cubilin (CUBN) and forms a complex designated cubam, which is essential for endocytosis/trancytosis of several ligands
  • CUBN functions as a multi-ligand receptor by binding to the transmembrane protein, AMN, and AMN -mediated glycosylation is crucial for cell surface targeting of CUBN in renal and intestinal cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MGA1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS