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FLASH GENE

Symbol

AMN

contributors: mct - updated : 12-12-2018

HGNC name	amnionless homolog (mouse)
HGNC id	14604

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MGA1 megaloblastic anemia 1
Location	14q32.3      Physical location : 103.388.992 - 103.397.178
Synonym name	visceral endoderm-specific type 1 transmembrane protein
Synonym symbol(s)	PRO1028

DNA

TYPE	functioning gene
STRUCTURE	8.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine colon   highly Respiratory lung         Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one VWFC domain

conjugated

GlycoP

isoforms

Precursor

HOMOLOGY

interspecies	ortholog to murine Amn
	homolog to rattus Amn

Homologene

FAMILY

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	modulating bone morphogenetic protein (BMP) receptor function, serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding
	necessary for efficient absorption of vitamin B12

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	functioning in the same pathway as cubilin (CUBN) and forms a complex designated cubam, which is essential for endocytosis/trancytosis of several ligands
	CUBN functions as a multi-ligand receptor by binding to the transmembrane protein, AMN, and AMN -mediated glycosylation is crucial for cell surface targeting of CUBN in renal and intestinal cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MGA1

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS