Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AMIGO2 contributors: - updated : 18-02-2006
HGNC name amphoterin induced gene 2
HGNC id 24073
Location 12q13.11      Physical location : 47.469.490 - 47.473.734
Synonym name alivin 1
Synonym symbol(s) ALI1, DEGA, AMIGO-2
DNA
TYPE functioning gene
STRUCTURE 4.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
DKFZp686G052 SFRS2IP 12q12-q14.3 splicing factor, arginine/serine-rich 2, interacting protein SLC38A1 12p11.21 solute carrier family 38, member 1 SLC38A2 12q solute carrier family 38, member 2 LOC387853 12 hypothetical gene supported by BC014370 SLC38A4 12q12-q13 solute carrier family 38, member 4 LOC390310 12 similar to transient receptor protein 6 AMIGO2 12q13.11 amphoterin induced gene 2 MGC16044 12q13.11 hypothetical protein MGC16044 LOC387854 12 LOC387854 LOC387855 12 LOC387855 FLJ21908 12q13.11 hypothetical protein FLJ21908 P11 12q13.1 26 serine protease EPAC 12q13.1 Rap1 guanine-nucleotide-exchange factor directly activated by cAMP FLJ20489 12q13.11 hypothetical protein FLJ20489 HDAC7A 12q13.1 histone deacetylase 7A VDR 12q13.1 vitamin D (1,25- dihydroxyvitamin D3) receptor MGC5576 12q13.1 hypothetical protein MGC5576 COL2A1 12q13.1 collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) LOC283389 12q13.12 hypothetical gene supported by BC029593 SENP1 12q12-q13 hypothetical gene supported by BC029593 PFKM 12q13.1 phosphofructokinase, muscle ASB8 12q13.12 ankyrin repeat and SOCS box-containing 8 LOC390311 12 similar to prohibitin LOC387856 12 similar to expressed sequence AI836003 LOC121275 12q13.12 similar to Olfactory receptor 10AD1 LOC341567 12q13.12 HANP1 FLJ31295 12q13.12 hypothetical protein FLJ31295 LOC390312 12 similar to olfactory receptor MOR160-1 ANP32D 12p11.1 acidic (leucine-rich) nuclear phosphoprotein 32 family, member D MGC35033 12q13.12 hypothetical protein MGC35033
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
 female systembreastmammary gland highly
Urinarybladder   highly
 kidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence for secretion
  • a transmembrane domain
  • six leucine-rich repeats (LRRs) flanked by
  • cysteine-rich LRR NH2- and COOH-terminal domains
  • one immunoglobulin domain close to the transmembrane region
  • HOMOLOGY
    Homologene
    FAMILY AMIGO family
    CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • promoting depolarization-dependent survival of the cerebellar granule neuron and inhibiting apoptosis
  • playing a potential etiologic role in gastric adenocarcinoma
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS