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FLASH GENE
Symbol AMIGO1 contributors: mct - updated : 23-08-2013
HGNC name adhesion molecule with Ig-like domain 1
HGNC id 20824
Location 1p13.3      Physical location : 110.049.446 - 110.052.336
Synonym name
  • amphoterin-induced gene
  • Alivin-2
  • Synonym symbol(s) KIAA1163, AMIGO, ALI2, AMIGO-1
    DNA
    TYPE functioning gene
    STRUCTURE 2.89 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2501 - 493 - 2006 16414120
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestivepancreas exocrine   moderately
    Nervousbrain     Homo sapiens
     spinal cord    
    Reproductivefemale systemovary  moderately
    Respiratorylung   highly
    Visualeye   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth   
    Nervouscentral    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte Homo sapiens
    Nervousneuron Homo sapiens
    Nervousoligodendrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six leucine-rich repeats (LRRs)
  • six cysteine-rich LRR NH2- and COOH-terminal domains
  • one immunoglobulin (Ig-like C2-type) domain
  • the transmembrane region
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Amigo
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • AMIGO family
  • CATEGORY adhesion , immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type I membrane protein
  • associated with axons of neuronal cells
  • basic FUNCTION
  • promoting growth and fasciculation of neurites from cultured hippocampal neurons
  • may be involved in fasciculation as well as myelination of developing neural axons
  • may have a role in regeneration as well as neural plasticity in the adult nervous system
  • may mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain
  • brain-enriched transmembrane immunoglobulin (Ig) superfamily protein
  • likely plays important roles in dendritic outgrowth during development, and could modulate the survival of developing and adult neurons
  • function-modulating auxiliary subunit for KCNB1, providing new insights into regulation of neuronal excitability
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text
  • neurogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AMIGO2
  • AMIGO3
  • increases KCNB1 conductance in a voltage-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS