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FLASH GENE
Symbol AMER2 contributors: mct - updated : 15-01-2018
HGNC name APC membrane recruitment protein 2
HGNC id 26360
Location 13q12.13      Physical location : -
Synonym name
  • hypothetical protein LOC219287
  • family with sequence similarity 123A
  • Synonym symbol(s) FLJ25477, FAM123A
    DNA
    TYPE functioning gene
    STRUCTURE 3.19 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 splicing 3198 - 671 - 2012 22128170
    2 splicing 2841 57.5 552 - 2012 22128170
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain     Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatum   
    Nervouscentral    Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal clusters of lysines termed K1 and K2 conserved between AMER2 and AMER1
  • a "SKIP" AA motif that mediated interaction with the microtubule tip tracking proteins end-binding protein 1 (MAPRE1) and MAPRE3--and therefore with microtubules
  • APC-binding domains A1 and A2
  • HOMOLOGY
    Homologene
    FAMILY
  • FAM123 family, AMER gene family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • novel negative regulator of Wnt signaling involved in brain development
  • negative regulator of Wnt/CTNNB1 signaling acting at the plasma membrane probably by inducing degradation of CTNNB1
  • coexpression of AMER2 and MAPRE1 generates stabilized microtubules at the plasma membrane
  • AMER1, AMER2, AMER3 have conserved and divergent cellular roles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • AMER2-MAPRE1-APC complex regulates cell migration by altering microtubule stability
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with components of the CTNNB1 destruction complex via APC, inhibits Wnt target gene expression, and alters neuroectodermal patterning
  • is a direct interaction partner of MAPRE1 and acts as regulator of microtubule stability together with MAPRE1
  • cell & other
  • interacted with and tracked with the plus end of dynamic microtubules
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS