basic FUNCTION
| negatively regulating WNT signaling by promoting ß-catenin (CTNNB) ubiquitination |
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repressor of canonical WNT signaling, mediating repressive effects on the ossification of bones that develop both by a cartilage scaffold (for example, long bones) and by direct differentiation from mesenchymal precursors (for example, calvaria) |
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implicated in WNT signaling through enhancement of cytoplasmic beta-catenin (CTNNB1) degradation |
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critical for differentiation of mesenchymal progenitor cells |
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AMER1, AMER2, AMER3 have conserved and divergent cellular roles |
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may be playing a role in nuclear pathways implicated in the transcriptional regulation of cellular differentiation programs |
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may be directly involved in the transcriptional regulation of cellular differentiation programs through interactions with WT1 and potentially other transcription factors in the kidney and in other tissues |
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exerts its negative regulatory role in Wnt signaling by acting as a scaffold protein for the CTNNB destruction complex and promoting stabilization of Axin at the plasma membrane |
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tumor suppressor, frequently inactivated in Wilms tumor |
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nuclear fraction of AMER1 plays likely a role in epigenetic silencing, an effect that may contribute to its function as a regulator of cellular differentiation and tumorigenesis |