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FLASH GENE
Symbol AMD1 contributors: mct - updated : 17-01-2015
HGNC name adenosylmethionine decarboxylase 1
HGNC id 457
Location 6q21      Physical location : 111.195.986 - 111.216.913
Synonym name
  • S-Adenosylmethionine decarboxylase
    • Synonym symbol(s) ADOMETDC, AMD, SAMDC
    EC.number 4.1.1.50
    DNA
    TYPE functioning gene
    STRUCTURE 81.09 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3200 - 265 - 1995 7789170
    9 - 3437 - 334 - 1995 7789170
    10 - 3350 - 305 - 1995 7789170
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    Text stem cell
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Amd1
    homolog to murine Amd1
    Homologene
    FAMILY eukaryotic AdoMetDC family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • important intermediate enzyme in polyamine biosynthesis
  • enzyme controlling a rate-liming step for the synthesis of spermidine, which is incorporated into EIF5A in the form of the non-standard amino acid hypusine
  • plays an essential role in embryonic development
  • pyruvoyl-dependent enzyme that catalyzes the formation of the aminopropyl group donor in the biosynthesis of the polyamines spermidine and spermine
  • ubiquitinated and degraded by the 26 S proteasome, and substrate-mediated acceleration of degradation is a unique finding
  • key enzyme for the biosynthesis of spermidine
  • key enzyme in the polyamine synthesis pathway, in regulating both ESC self-renewal and differentiation to the neural lineage
  • major regulator of ESC self-renewal and its essential role lies in its regulation of MYC levels within the cell
  • implicated in ESC self-renewal and directed differentiation of ESCs to neural precursor cells (NPCs)
  • both AMD1 and ODC1 are essential regulators of ESCs and function to ensure high polyamine levels to promote ESC self-renewal
  • AMD1-stimulated different complete network was involved in AMD1 activation with cytoplasm ubiquitin specific peptidase (tRNA-guanine transglycosylase) to nucleus paired box-induced mRNA processing
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer of two alpha and two beta chains
  • polyamine–hypusine axis is a new tumour suppressor network regulating apoptosis
    • INTERACTION
    DNA
    RNA
    small molecule cofactor,
    pyruvoyl group
    protein
    cell & other
    REGULATION
    activated by Putrescine (1,4-diaminobutane), that activates the autoprocessing and decarboxylation reactions ofAMD1, a critical enzyme in the polyamine biosynthetic pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    required for maintenance of the embryonic stem cell (ESC) state
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS