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FLASH GENE
Symbol AMBP contributors: - updated : 18-04-2005
HGNC name alpha-1-microglobulin/bikunin precursor
HGNC id 453
Location 9q32-q33      Physical location : 116.822.409 - 116.840.752
Synonym name immunocalin
Synonym symbol(s) ITI, ITIL, HC, HCP
DNA
TYPE functioning gene
STRUCTURE 18.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence   ALU
MAPPING cloned Y linked   status confirmed
Physical map
SLC31A1 9q31-q32 solute carrier family 31 (copper transporters), member 1 CDC26 9q32 cell division cycle 26 PRPF4 9q31-q33 PRP4 pre-mRNA processing factor 4 homolog (yeast) MGC4734 9q33.1 hypothetical protein MGC4734 WDR31 9q33.1 WD repeat domain 31 BSPRY 9q33.1 B-box and SPRY domain containing MGC12904 9q33.1 hypothetical protein MGC12904 ALAD 9q33.3 aminolevulinate, delta-, dehydratase POLE3 9q33 polymerase (DNA directed), epsilon 3 (p17 subunit) C9orf43 9q33.1 chromosome 9 open reading frame 43 RGS3 9q31-q33 regulator of G-protein signalling 3 FLJ31713 9q33.1 hypothetical protein FLJ31713 LOC392385 9 similar to programmed cell death 2 isoform 1; zinc finger protein Rp-8; programmed cell death 2/Rp8 homolog KIAA1952 9q33.1 KIAA1952 protein AMBP 9q32-q33 alpha-1-microglobulin/bikunin precursor KIF12 9q33.1 kinesin family member 12 COL27A1 9q33.1 collagen, type XXVII, alpha 1 ORM1 9q32 orosomucoid 1 ORM2 9q32 orosomucoid 2 AKNA 9q32 AT-hook transcription factor AKNA CIP98 9q33.1 CASK-interacting protein CIP98 ATP6V1G1 9q33.1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 1 DKFZp547P234 9q33.1 DKFZp547P234 protein LOC389786 9 LOC389786
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   highly
Lymphoid/Immunespleen    
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two BPTI/Kunitz inhibitor domains (58AA motif containing three intrachain disulfide bonds) domains
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY lipocalin family Kernel group)
    CATEGORY immunity/defense , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION inhibition of neurotrophil chemotaxis to endotoxin activated serum
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • expressed in plasma either as a free form or in covalent complexes with albumine IgA and bikunin precursor (ITIL)
  • complexing with ITIH1, ITIH2, ITIH3 or ITIH4, to form alpha type inhibitor (respectively inter- and pre-)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS