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FLASH GENE
Symbol ALYREF contributors: mct/ - updated : 24-10-2014
HGNC name Aly/REF export factor
HGNC id 19071
Location 17q25.3      Physical location : -
Synonym name
  • b-zip-enhancing factor
  • transcriptional coactivator Aly/REF
  • ally of AML-1 and LEF-1
  • THO complex 4
  • Synonym symbol(s) BEF, ALY, Tho4, REF, THOC4
    DNA
    TYPE functioning gene
    STRUCTURE 3.75 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1113 - 264 - 2008 18562279
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain   lowly
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain comes into contact with the viral RNA, which becomes engaged in an extensive network of synergistic interactions with both ALYREF and ORF57
  • HOMOLOGY
    interspecies ortholog to murine Refbp1
    homolog to rattus Rn.6994
    homolog to xenopus Xl.3859
    homolog to zebrafish Dr.9815
    Homologene
    FAMILY
  • THOC4 family
  • CATEGORY chaperone/stress , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • regulating dimerization, DNA binding and transcriptional activity of basic region-leucine zipper (bZIP) proteins
  • mediates context-dependent transcriptional activation by facilitating functional collaboration of proteins in the TCR-alpha enhancer complex
  • nuclear speckle protein implicated in mRNA export
  • playing a central role in T-cell enhancer function and oncogene activation
  • DDX39, DDX39B play an essential role for cellular mRNA export by recruiting the adaptor protein ALYREF to spliced and unspliced mRNAs
  • ALYREF, THOC1 and DDX39B form a highly integrated unit to associate with the spliced mRNA and function in mRNA export
  • emerges as a novel E2F2-interacting protein and a relevant modulator of E2F-responsive gene expression
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcriptional coactivator
    PATHWAY
    metabolism
    signaling
    a component SARNP, THOC4, and BAT1 form an ATP-dependent trimeric complex, and BAT1 bridges the interaction between SARNP and THOC4
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to LEF1 and AML
  • interacting with DDX48
  • binds phosphoinositides, and this action is regulated by Akt-mediated phosphorylation
  • is a physiological target of nuclear PI3K signaling, and nuclear PI3K signaling mediates both cell proliferation and mRNA export functions of ALYREF
  • with SARNP, associate with TREX in an ATP-dependent manner, and BAT1 mediates the association between these proteins and the THO complex to form TREX
  • transcriptional co-activator, associating with DNA-bound E2F2 and represses its transcriptional activity
  • interaction of Herpes simplex virus 1 (HSV-1) protein ICP27 with ALYREF contributes to efficient viral mRNA export
  • cell & other
    REGULATION
    Other TCRAlpha enhancer
    regulated by nuclear PI3K signaling that mediates both cell proliferation and mRNA export functions of THOC4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in normal proliferative cells, but poorly in high-grade cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS